StaupriMide
|
|
StaupriMide 속성
- 밀도
- 1.52±0.1 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- DMSO: >20mg/mL
- 산도 계수 (pKa)
- 9.51±0.70(Predicted)
- 물리적 상태
- 노란색 고체
- 색상
- 흰색에서 베이지색
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO의 솔루션은 -20°C에서 최대 2개월 동안 보관할 수 있습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| WGK 독일 | 3 | ||
|---|---|---|---|
| HS 번호 | 2934999090 |
| 그림문자(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
|
||||||||||||||||||||||||||||
| 예방조치문구: |
|
StaupriMide C화학적 특성, 용도, 생산
개요
Stauprimide is a small molecule that increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues (EC50 = 0.3 μM). It specifically inhibits the nuclear localization of NME2, which results in the suppression of c-용도
Labelled Stauprimide (S684700). It is an enhancer stem cell differentiation into endoderm.일반 설명
A cell-permeable ESCs (Embryonic Stem Cells) EMT (Epithelial-Mesenchymal Transition) inducer that is reported to prime/sensitize human and murine ESC cultures for much more enhanced/efficient differentiation into progenitor cells of multiple lineages, including Activin A- (Cat. No. 114700) induced definitive endoderm differentiation (60% differentiation from murine R1 ESCs with 5 ng/ml Activin A and 200 nM Spd), ATRA- (Cat. No. 554720) induced neuronal progenitor differentiation, and BMP-4- (Cat. No. 203642) induced mesoderm differentiation, under suboptimal lineage specifying stimuli concentrations and often serum-free conditions, while Spd sensitization alone does not induce any ESCs differentiation. Spd is shown to interact with NME2/DNPK B/PUF and prevent NME2 nuclear localization and c-myc transcription in murine R1 ESC cultures (46% and 85% drop in c-myc mRNA in 24 h, respectively, with 200 nM and 500 nM Spd), which accounts for, at least in part, its EMT induction activity. Although a structural analog of the broad-spectrum kinase inhibitors Staurosporine (Cat. Nos. 569396 and 569397) and UCN-01 (Cat. No. 539644), Spd exhibits significant kinase inhibitory activities only at elevated concentrations, but not at concentrations ≤500 nM typically used in EMT induction.StaupriMide 준비 용품 및 원자재
원자재
준비 용품
StaupriMide 공급 업체
글로벌( 59)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; |
laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 |
admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
| Aurisco Pharmaceutical (Tianjin) Inc. | 022-59885855 |
liuyujie@aurisco.com | China | 96 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 |
shchemsky@sina.com | China | 15421 | 60 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 |
3007715519@qq.com | China | 18739 | 57 |