AMG 925
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AMG 925 속성
- 끓는 점
- 712.3±70.0 °C(Predicted)
- 밀도
- 1.48±0.1 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- insoluble in DMSO; insoluble in H2O; insoluble in EtOH
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 13.41±0.10(Predicted)
- 색상
- Light yellow to yellow
안전
AMG 925 C화학적 특성, 용도, 생산
개요
AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC50s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC50 = 2.22 μM). AMG 925 also binds to FLT3ITD, FLT3D835Y, FLT3D835H, FLT3K663Q, and FLT3N841I (Kds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC50s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.AMG 925 준비 용품 및 원자재
원자재
2,4-Pyrimidinediamine, N4-(trans-4-methylcyclohexyl)-
1401033-82-6
2,4-Pyrimidinediamine, 5-iodo-N4-(trans-4-methylcyclohexyl)-
9H-Pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine, 9-(trans-4-methylcyclohexyl)-
AMG-925 Intermediate
트랜스-4-메틸사이클로헥실아민
tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
트랜스-4-메틸시클로헥실아민염산염
2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-나프티리딘염화물
글리콜산
플로로피리딘
준비 용품
AMG 925 공급 업체
글로벌( 62)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 17702719238 |
sales@sun-shinechem.com | China | 950 | 64 |
Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 |
meilunui@163.com | China | 4672 | 58 |
Shanghai Topbiochem Technology Co., Ltd | 021-58170097 |
info@topbiochem.com | China | 9465 | 58 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 |
info@chemexpress.com | China | 7553 | 61 |
AdooQ BioScience, LLC | +1 (866) 930-6790 |
info@adooq.com | United States | 2784 | 58 |