만데릭산

만데릭산
만데릭산 구조식 이미지
카스 번호:
90-64-2
한글명:
만데릭산
동의어(한글):
만데릭산;만델산;만델릭애씨드
상품명:
DL-Mandelic acid
동의어(영문):
Mandelic;Amygdalinic acid;Mandellic acid;Amygdalic acid;Almond acid;Pregabalin EP Impurity C;alpha-Hydroxy-benzeneacetic acid;(2RS)-2-Hydroxy-2-phenylacetic Acid;-MandeL;Uromaline
CBNumber:
CB3287471
분자식:
C8H8O3
포뮬러 무게:
152.15
MOL 파일:
90-64-2.mol
MSDS 파일:
SDS

만데릭산 속성

녹는점
119-121 °C (lit.)
끓는 점
214.6°C (rough estimate)
알파
[α]D20 -0.5~+0.5° (c=2, H2O)
밀도
1.30
증기압
0.01 Pa (50 °C)
굴절률
1.4810 (estimate)
저장 조건
Store below +30°C.
용해도
139g/L
산도 계수 (pKa)
3.85(at 25℃)
물리적 상태
결정 또는 결정성 분말
색상
하얀색
수소이온지수(pH)
2.3 (10g/l, H2O)
냄새
희미한 냄새
optical activity
[α]/D 0±1°, c = 5 in H2O
수용성
150g/L(20℃)
감도
Light Sensitive
Merck
14,5717
BRN
510011
InChIKey
IWYDHOAUDWTVEP-UHFFFAOYSA-N
LogP
0.5 at 23℃
CAS 데이터베이스
90-64-2(CAS DataBase Reference)
NIST
Benzeneacetic acid, «alpha»-hydroxy-(90-64-2)
EPA
Mandelic acid (90-64-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 36/37/38-22
안전지침서 22-24/25-37/39-26-36
WGK 독일 3
RTECS 번호 OO6300000
TSCA Yes
HS 번호 29181990
기존화학 물질 KE-20350
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 GHS hazard pictograms P280, P305+P351+P338, P310
예방조치문구:
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
0
2 0

만데릭산 C화학적 특성, 용도, 생산

화학적 성질

White rhomboidal crystals, decompose when exposed to light. Soluble in ether and isopropanol, soluble in ethanol and water; R-form melting point is 133°C, [α]-159.73° (ethanol), gradually racemic at 160°C. S-form melting point is 133.8°C, [α]+156.57° (water).

용도

DL-Mandelic acid may be used as an analytical reference standard for the determination of DL-mandelic acid in:
Human urine samples by high performance liquid chromatography (HPLC) equipped with ultraviolet (UV) detector.
Rat urine samples by gas chromatography-mass spectrometry (GC-MS) with selected ion monitoring (SIM) detection.

정의

ChEBI: Mandelic acid is a 2-hydroxy monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by phenyl and hydroxyl groups. It has a role as an antibacterial agent and a human xenobiotic metabolite. It is a 2-hydroxy monocarboxylic acid and a member of benzenes. It derives from an acetic acid. It is a conjugate acid of a mandelate. Exists in stereoisomeric forms. The properties are those of the dl-form.

제조 방법

Mandelic acid can be prepared by the hydrolysis of amygdalin with sulfuric acid or of mandelonitrile with hydrochloric acid. The mandelonitrile can be prepared by the action of hydrocyanic acid on benzaldehyde, and by the action of sodium or potassium cyanide on the sodium bisulfite addition product of benzaldehyde. The procedure described differs from earlier methods in that the sodium bisulfite addition compound of benzaldehyde is prepared in the presence of sodium cyanide and the nitrile is formed immediately.
synthesis of mandelic acid

일반 설명

DL-Mandelic acid is an aromatic hydrocarbon metabolite of styrene.

위험도

Toxic by ingestion.

Safety Profile

Poison by intramuscular route. Moderately toxic by ingestion. Continued absorption can cause kidney irritation. When heated to decomposition it emits acrid smoke and irritating fumes.

만데릭산 준비 용품 및 원자재

원자재

준비 용품


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