Toremifene citrate
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Toremifene citrate 속성
- 녹는점
- 160-162°C
- 끓는 점
- 146-148C
- 밀도
- 1,045g/cm
- 굴절률
- 1,416-1,418
- 저장 조건
- 2-8°C
- 용해도
- DMSO: >10mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- Merck
- 14,9550
- 안정성
- 감광성
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,N,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-50/53-41-22 | ||
안전지침서 | 26-37/39-61-60-39 | ||
유엔번호(UN No.) | UN 3077 9 / PGIII | ||
WGK 독일 | 3 | ||
RTECS 번호 | KH2156700 |
Toremifene citrate C화학적 특성, 용도, 생산
개요
Toremifene (citrate) is an orally bioavailable selective estrogen receptor modulator (SERM) that evokes tissue-dependent effects similar to that of tamoxifen . It has been shown to block estrogen-stimulated growth of MCF-7 breast cancer cells grown in tissue culture, to inhibit ovariectomy-induced bone loss in rats, and to stimulate endometrial growth similar to that of tamoxifen.화학적 성질
White-to-Off-White Solid용도
Toremifene citrate salt has been used:- in cell-based ELISA
- as a positive control to detect its antiviral activity against Ebola virus (EBOV)
- to treat MCF7 and T47D breast cancer cell lines
일반 설명
Toremifene, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine(Fareston), differs structurally fromtamoxifen only by having a chloroethyl group (rather than anethyl group) attached to the triphenylethylene structure. Asmight be expected, the pharmacological actions of toremifeneand tamoxifen are quite similar. Toremifene is also a SERM,with estrogen antagonist action in breast tissue but agonist actionin the endometrium, on bone tissue, and on serum lipidprofiles. Recent clinical data indicate that the incidence ofendometrial cancer is lower with toremifene use than with tamoxifen. Toremifene is used in the treatment of metastaticbreast cancer in postmenopausal women.Toremifene citrate 준비 용품 및 원자재
원자재
준비 용품
Toremifene citrate 공급 업체
글로벌( 271)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 |
ada@sh-teruiop.com | China | 892 | 58 |
Hebei Duling International Trade Co. LTD | +8618032673083 |
sales05@hbduling.cn | China | 15755 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 524 | 58 |
Shanghai Aosiris new Material Technology Co., LTD | +8617513190836 |
wrjmoon2000@163.com | China | 231 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21700 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9354 | 55 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |