5,5-DIMETHYL-1-PYRROLINE N-OXIDE
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5,5-DIMETHYL-1-PYRROLINE N-OXIDE 속성
- 녹는점
- 25-29 °C (lit.)
- 끓는 점
- 75 °C/0.4 mmHg (lit.)
- 밀도
- 1.015 g/mL at 25 °C (lit.)
- 굴절률
- n
20/D 1.496(lit.)
- 인화점
- 204 °F
- 저장 조건
- -20°C
- 용해도
- DMSO(최대 25mg/ml) 또는 에탄올(최대 25mg/ml)에 용해됩니다.
- 물리적 상태
- 담황색 고체 또는 오일.
- 산도 계수 (pKa)
- 2.47±0.40(Predicted)
- 색상
- 옅은 노랑
- Merck
- 14,3393
- BRN
- 107603
- 안정성
- 안정적이지만 빛에 민감하고 흡습성이 있으며 열에 민감합니다. 불활성 가스하에 어두운 곳에 보관하고 차갑게 보관하십시오. 강한 산화제, 습기와 호환되지 않습니다.
- InChIKey
- VCUVETGKTILCLC-UHFFFAOYSA-N
- CAS 데이터베이스
- 3317-61-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
5,5-DIMETHYL-1-PYRROLINE N-OXIDE C화학적 특성, 용도, 생산
개요
Free radicals are highly reactive, short-화학적 성질
white to faintly yellow solid용도
5,5-Dimethyl-1-pyrroline N-oxide is a reagent generally used either as a free-radical spin-trapping agent, or electrophilic component during the synthesis of pyrrolidine derivatives. It may also be considered as 1,3-dipole in cycloaddition processes.제조 방법
To a three-necked round bottom flask equipped with a condenser, addition funnel, thermometer, and mechanical stirrer and containing 300 ml. 95% ethanol precooled to 2°C is added, all at once, 14.5 g (0.1 mole) 4-methyl-4-nitropentanol, and 13.1 g (1.2 mole) zinc dust. With rapid agitation, the glacial acetic acid (24.0 g, 0.4 mole) is added dropwise over a 1-hr period while maintaining the reaction temperature below 15°C. The mixture is stirred vigorously for 2 hr and then stored in the refrigerator for 2 days, at approximately 1°C. Then the zinc acetate is filtered and rinsed with 100 ml of ethanol. The combined ethanol factions are rotoevapo-rated to give the crude nitrone. The crude nitrone is dissolved in a 200 ml portion of dichloromethane and the latter washed two times with saturated sodium bicarbonate solution. The organic layer is dried over sodium sulfate and the solvent rotoevaporated, to give 10.7 (94% yield) of the crude nitrone. The product was purified by double distillation (b.p. 53°C, 0.1 Torr), to give 6.8 g (60%) of the pure nitrone as a white hygroscopic solid. The H1 NMR (400 MH CDC13, Me4Si) is 6.80 (t, 2H, methylene bound to quaternary C, J = 7.2Hg), 1.43 (s, 6H, methyl), C13NMr (100 MH2, CDC13, Me4 Si) 5=132.4 (Vinyl), 73.5 (quaternary), 34.1 (Allyl), 25.3 (methylene bound to quaternary C), 24.4 (methyls).생물학적 활성
Water soluble nitric oxide spin trap; allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin resonance (ESR). Has a high reaction rate constant for superoxide and hydroxyl radicals, and distinguishes simultaneously among a variety of important biologically generated free radicals.Physiological effects
5,5-dimethyl-1-pyrroline N-oxide is used as a spin trap for the study of radicals formed by enzymatic acetaldehyde oxidation. It has a role as a neuroprotective agent and a spin trapping reagent.5,5-DIMETHYL-1-PYRROLINE N-OXIDE 준비 용품 및 원자재
원자재
준비 용품
5,5-DIMETHYL-1-PYRROLINE N-OXIDE 공급 업체
글로벌( 217)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 19536 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29823 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
5,5-DIMETHYL-1-PYRROLINE N-OXIDE 관련 검색:
피롤 3,3,5,5-사메틸-1-피롤린 N-옥사이드
5,5-DIMETHYL-1-PYRROLINE N-OXIDE
2-ETHOXYCARBONYL-2-METHYL-3,4-DIHYDRO-2H-PYRROLE-1-OXIDE
5,5-DIMETHYL-4-HYDROXYMETHYL-1-PYRROLINE N-OXIDE
3-[[2-(BIOTINAMIDO)ETHYL]DITHIO]PROPIONIC ACID 4'-(HYDROXYMETHYL)DMPO ESTER
5-METHYL-5-PHENYLPYRROLINE N-OXIDE
2-Phenyl-4,4-dimethyl-1-pyrroline 1-oxide
2,2'-[p-Phenylenebis(vinylene)]bis(5,5-dimethyl-1-pyrroline 1-oxide)
2-(2-Methoxy-2-phenylethenyl)-4,4-dimethyl-1-pyrroline 1-oxide
glutathionyl-5,5-dimethyl-1-pyrroline N-oxide
2-(2-Dimethylamino-2-phenylethenyl)-4,4-dimethyl-1-pyrroline 1-oxide
2-(Hydroxyimino)methyl-5,5-dimethyl-1-pyrroline 1-oxide
2-Cyano-5,5-dimethyl-1-pyrroline 1-oxide
2-tert-Butyl-5,5-dimethyl-1-pyrroline 1-oxide
2-Styryl-4,4-dimethyl-1-pyrroline 1-oxide
5,5-DIMETHYL-1-PYRROLINE, N-OXIDE, [2-14C]-
5,5-DIMETHYL-4-PHENYL-1-PYRROLINE N-OXIDE