케토프로펜

케토프로펜
케토프로펜 구조식 이미지
카스 번호:
22071-15-4
한글명:
케토프로펜
동의어(한글):
케토프로펜;케토프로펜(KETOPROFEN)
상품명:
Ketoprofen
동의어(영문):
2-(3-BENZOYLPHENYL)PROPANOIC ACID;ORUVAIL;ketoprofene;ORUDIS;Profenid;KETOPROFEN USP;2-(3-BENZOYLPHENYL)PROPIONIC ACID;aneol;Dexal;Topre
CBNumber:
CB3299418
분자식:
C16H14O3
포뮬러 무게:
254.29
MOL 파일:
22071-15-4.mol

케토프로펜 속성

녹는점
93-96°C
끓는 점
357.5°C (rough estimate)
밀도
1.1565 (rough estimate)
굴절률
1.5600 (estimate)
저장 조건
2-8°C
용해도
클로로포름과 메탄올에 약간 용해됩니다.
산도 계수 (pKa)
pKa 5.94(MeOH/H2O) (Uncertain)
물리적 상태
고체
물리적 상태
단단한 모양
색상
흰색에서 황백색까지
수용성
209mg/L(상온)
Merck
14,5305
InChIKey
DKYWVDODHFEZIM-UHFFFAOYSA-N
CAS 데이터베이스
22071-15-4(CAS DataBase Reference)
NIST
Ketoprofen(22071-15-4)
EPA
Benzeneacetic acid, 3-benzoyl-.alpha.-methyl- (22071-15-4)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T
위험 카페고리 넘버 25-36/37/38-23/24/25
안전지침서 26-45-36/37/39
유엔번호(UN No.) 2811
WGK 독일 3
RTECS 번호 UE7570000
TSCA Yes
위험 등급 6.1(b)
포장분류 III
HS 번호 29183000
독성 LD50 orally in rats: 101 mg/kg (Ueno)
기존화학 물질 KE-02767
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2 0

케토프로펜 MSDS


2-(3-Benzoylphenyl)propionic acid

케토프로펜 C화학적 특성, 용도, 생산

화학적 성질

White Crystalline Solid

용도

Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.

정의

ChEBI: An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.

Indications

Ketoprofen (Orudis) is indicated for use in rheumatoid and osteoarthritis, for mild to moderate pain, and in dysmenorrhea. The most frequently reported side effects are GI (dyspepsia, nausea, abdominal pain, diarrhea, constipation, and flatulence) and CNS related (headache, excitation). Edema and increased blood urea nitrogen have also been noted in more than 3% of patients. Ketoprofen can cause fluid retention and increases in plasma creatinine, particularly in the elderly and in patients taking diuretics.

일반 설명

Ketoprofen (Orudis, Rhodis) and suprofen (Profenal) areclosely related to fenoprofen in their structures, properties,and indications. Even though ketoprofen has been approvedfor OTC use (Orudis KT, Actron), its GI side effects aresimilar to indomethacin, and therefore its useshould be closely monitored, especially in patients with GIor renal problems.

색상 색인 번호

Ketoprofen is an anti-inflammatory drug, used both topically and systemically. It is above all a photoaller- gen, responsible for photoallergic or photo-worsened contact dermatitis, with sun-induced, progressive, severe, and durable reactions. Recurrent photosensitiv- ity is possible for many years. Photosensitivities are expected to thiophene-phenylketone derivatives such as tiaprofenic acid and suprofen, to ketoprofen esters such as piketoprofen, and to benzophenone derivatives (see above) such as fenofibrate and benzophenone-3. Concomitant photosensitivities without clinical rel- evance have been observed to fenticlor, tetrachloro- salicylanilide, triclosan, tribromsalan, and bithionol.

Pharmacokinetics

Ketoprofen is rapidly and nearly completely absorbed on oral administration, reaching peak plasma levels within 0.5 to 2 hours. It is highly plasma protein bound (99%) despite a lower acidity (pKa = 5.9) than some other NSAIDs. Wide variation in plasma half-lives has been reported. It is metabolized by glucuronidation of the carboxylic acid, CYP3A4 and CYP2C9 hydroxylation of the benzoyl ring, and reduction of the keto function.

Clinical Use

Ketoprofen, unlike many NSAIDs, inhibits the synthesis of leukotrienes and leukocyte migration into inflamed joints in addition to inhibiting the biosynthesis of prostaglandins. It stabilizes the lysosomal membrane during inflammation, resulting in decreased tissue destruction. Antibradykinin activity also has been observed. Bradykinin is released during inflammation and can activate peripheral pain receptors. In addition to anti-inflammatory activity, ketoprofen also possesses antipyretic and analgetic properties. Although it is less potent than indomethacin as an anti-inflammatory agent and an analgetic, its ability to produce gastric lesions is about the same.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, rectal, and intraperitoneal routes. Human systemic effects by an unspecified route:headache, nausea or vomiting, and degenerative changesin the brain, changes in kidney tubules. An experimentalteratogen.

케토프로펜 준비 용품 및 원자재

원자재

준비 용품


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