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다이페녹시레이트

다이페녹시레이트
다이페녹시레이트 구조식 이미지
카스 번호:
915-30-0
한글명:
다이페녹시레이트
동의어(한글):
다이페녹시레이트
상품명:
Diphenoxylate
동의어(영문):
DIPHENOXYLATE;DiphenoxyleteHCl;Diphenoxyletehydrochloride;HYPPXZBJBPSRLK-UHFFFAOYSA-N;Diphenoxylate hydrochloride CP2000,BP98;ethyl1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate;2,2-diphenyl-4-(4-carbethoxy-4-phenylpiperidino)butyronitrile;1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecoticacidethylester;1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-isonipecoticaciethylester;1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-isonipecoticacidethylester
CBNumber:
CB3301641
분자식:
C30H32N2O2
포뮬러 무게:
452.59
MOL 파일:
915-30-0.mol

다이페녹시레이트 속성

끓는 점
602.3±55.0 °C(Predicted)
밀도
1.123±0.06 g/cm3(Predicted)
산도 계수 (pKa)
pKa 7.1 (Uncertain)
CAS 데이터베이스
915-30-0(CAS DataBase Reference)
NIST
Diphenoxylate(915-30-0)

안전

위험품 표기 T+
위험 카페고리 넘버 26/27/28-42/43
안전지침서 22-26-45
유해 물질 데이터 915-30-0(Hazardous Substances Data)

다이페녹시레이트 MSDS


Diphenoxylate

다이페녹시레이트 C화학적 특성, 용도, 생산

Originator

Lomotil,Searle,US,1960

용도

This drug is a structural analog of meperidine and loperamide; however, it practically duplicates all of the pharmacological properties of loperamide. Being analogous to loperamide, it is mainly used for treating diarrhea. Synonyms for this drug are fentanest, leprofen, and others.

용도

Antiperistaltic.

Indications

Diphenoxylate (marketed in combination with atropine as Lomotil in the United States) is chemically related to both analgesic and anticholinergic compounds. It is as effective in the treatment of diarrhea as the opium derivatives, and at the doses usually employed, it has a low incidence of central opioid actions. Diphenoxylate is rapidly metabolized by ester hydrolysis to the biologically active metabolite difenoxylic acid.

정의

ChEBI: A piperidinecarboxylate ester that is the ethyl ester of difenoxin.

Manufacturing Process

A mixture of 23 parts of the ethyl ester of 4-phenylisonipecotic acid and 15 parts of 2,2-diphenyl-4-
omobutyronitrile in 19 parts of xylene is heated for 24 hours at 100-120°C and then cooled and filtered to remove the precipitate of the hydro
omide of the ethyl ester of 4-phenylisonipecotic acid. The filtrate is then extracted with dilute hydrochloric acid and the extract is rendered alkaline by addition of concentrated aqueous potassium hydroxide and extracted with ether. This ether extract is treated with gaseous hydrogen chloride. The resulting precipitate is collected on a filter. The hydrochloride of the ethyl ester of 2,2-diphenyl-4-(4'-carboxy-4'-phenyl-1'- piperidino)butyronitrile thus obtained melts at about 220.5-222°C. See meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl ester.

상표명

Diarphem;Diarsed-neomycin;Diatro;Eldox;Logen;Lomanate;Lomax;Lomotil liquid;Lonox;Protector;Reasec;Saleton;Sedistal.

Therapeutic Function

Antidiarrheal

World Health Organization (WHO)

Diphenoxylate, a derivative of pethidine without analgesic activity, is used in the symptomatic treatment of acute and chronic diarrhoea to reduce intestinal motility. There is no clear evidence that it has any beneficial effect in diminishing fluid losses and it has been associated with central nervous system toxicity, particularly in children, which results in anorexia, nausea and vomiting, headache, drowsiness, confusion, insomnia, dizziness, restlessness, euphoria and depression. The World Health Organization recommends that diphenoxylate should not be used for the management of diarrhoea in children and many countries have since withdrawn products containing this compound indicated for paediatric use. (Reference: (WHORUD) The Rational Use of Drugs, , , 1990)

일반 설명

Diphenoxylate is a weak opioid agonist and isavailable combined with atropine (Lomotil) for use as an antidiarrhealagent. At low doses, the opioid effect is minimal,and the atropine is added to dissuade abuse. One studyfound both codeine and loperamide to be superior to diphenoxylatefor treating chronic diarrhea.83 The manufacturerhas strict dosing guidelines for pediatric use because opioidintoxication and deaths from diphenoxylate have beenreported.

Clinical Use

Lomotil is recommended as adjunctive therapy in the management of diarrhea. It is contraindicated in children under 2 years old and in patients with obstructive jaundice.

부작용

Adverse reactions often caused by the atropine in the preparation include anorexia, nausea, pruritus, dizziness, and numbness of the extremities.

Chemical Synthesis

Diphenoxylate, ethyl ester of 1-(3-cyano-3,3-diphenylpropyl)- 4-phenylpiperidine-4-carboxylic acid (3.1.58), is also a drug of 4-phenylpiperidine series. In practice there are two ways of making it. The first way is by the alkylation of the ethyl ester of 4-phenylpiperidine-4-carboxylic acid (3.1.56) with 2,2-diphenyl-4-bromobutyronitrile, which in turn is synthesized from 1-benzyl-4-phenyl-4-cyanopiperidine. The product undergoes ethanolysis in the presence of acid, followed by benzylation. The second way is a synthesis accomplished by alkylation of diphenylacetonitrile using ethyl ester of 1-(2-chloroethyl)-4-phenylpiperidine-4-carboxylic acid (3.1.57), which is synthesized by reaction of ethyl ester of 4-phenylpiperidine-4-carboxylic acid with β-chloroethanol or ethylenoxide with the subsequent substitution of hydroxyl group, which results from the opening of the epoxide ring, by chlorine via action of thionyl chloride [37,38].

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