ChemicalBook >제품 카탈로그 >GDC-0853

GDC-0853

GDC-0853 구조식 이미지

카스 번호:: 1434048-34-6

상품명:: GDC-0853

동의어(영문):: GDC0853;CS-2241;EOS-61209;FENEBRUTINIB;GDC-0853;GDC 0853;GDC-0853 (RG7845);GDC-0853/Fenebrutinib;FENEBRUTINIB (GDC-0853);inhibit,Inhibitor,GDC0853,GDC 0853,Fenebrutinib,Btk,Bruton tyrosine kinase;2-1,6-Dihydro-3'-(hydroxymethyl)-1-methyl-5-5-(2S)-2-methyl-4-(3-oxetanyl)piperazin-1-ylpyridin-2-ylamino-6-oxo3,4'-bipyridin-2'-yl-3,4,7,8-tetrahydro-7,7-dimethyl-2H-cyclopenta4,5pyrrolo1,2-apyrazin-1(6H)-one

CBNumber:: CB33142405

분자식:: C37H44N8O4

포뮬러 무게:: 664.8

MOL 파일:: 1434048-34-6.mol

속성

안전

용도

공급 업체 73

GDC-0853 속성

끓는 점: 936.3±65.0 °C(Predicted)

밀도: 1.42±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMF:20.0(Max Conc. mg/mL);30.08(Max Conc. mM)
DMSO:17.0(Max Conc. mg/mL);25.57(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.5(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);7.52(Max Conc. mM)

물리적 상태: 결정성 고체

산도 계수 (pKa): 13.15±0.10(Predicted)

안전

GDC-0853 C화학적 특성, 용도, 생산

개요

GDC-0853 is an orally bioavailable, selective, and reversible Bruton’s tyrosine kinase (BTK) inhibitor with IC₅₀s ranging from 2-9 nM for basophil activation, B cell receptor activation, and constitutive p-BTK activity in whole blood lysates. In rats, treatment for longer than 7 days leads to pancreatic toxicity but it does not occur in mice or dogs, even at higher doses. Formulations containing GDC-0853 were well-tolerated in Phase I clinical trials and are in additional clinical trials for rheumatoid arthritis, lupus erythematosus, lymphoma, and leukemia.

용도

Fenebrutinib is a selective and reversible oral small-molecular BTK inhibitor for the treatment of rheumatoid arthritis and systemic lupus erythematosus.

GDC-0853 준비 용품 및 원자재

원자재

준비 용품

GDC-0853 공급 업체

글로벌( 73)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Shanghai XingMo Biotechnology Co., Ltd.	13524779951	2075692521@qq.com	China	309	55