Plecanatide
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Plecanatide 속성
- 끓는 점
- 2120.0±65.0 °C(Predicted)
- 밀도
- 1.47±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 3.61±0.21(Predicted)
- InChIKey
- NSPHQWLKCGGCQR-DLJDZFDSSA-N
안전
유해 물질 데이터 | 467426-54-6(Hazardous Substances Data) |
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Plecanatide C화학적 특성, 용도, 생산
용도
Plecanatide is used in the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. It works as a laxative by drawing water in to the gastrointestinal tract thereby softening stool and encouraging its natural passage.효소 저해제
This uroguanylin analogue (FW = 1681.90 g/mol; CAS 467426-54-6), also known by the codename SP-304, binds to and activates guanylate cyclase-C (GC-C) receptors (EC50 ≈ 0.3 μM) expressed on the epithelial cells lining turn sequentially activates protein kinase G-II and the chloride channel known as the Cystic Fibrosis Transmembrane-conductance Regulator (CFTR) to regulate ion and fluid transport, to promote epithelial cell homeostasis, and to maintain barrier function in the GI mucosa. Plecanatide is a hexadecapeptide that is structurally identical to uroguanylin, except for an glutamate substitution at position-3. Oral treatment with plecanatide at a dose range between 0.05-2.5 mg/kg per day is as effective as once-daily treatment with 5-amino salicylic acid (100 mg/kg) or sulfasalazine (80 mg/kg). Amelioration of colitis by the treatment with plecanatide or dolcanatide was not dose-dependent, most likely due to saturation of available GC-C receptors.Plecanatide 준비 용품 및 원자재
원자재
준비 용품
Plecanatide 공급 업체
글로벌( 157)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
Apextide Co Ltd | +undefined15700198315 |
senjie.hou@sinopep.com | China | 71 | 58 |
Shanghai Chinqesen Biotechnology Co., Ltd. | +86-16628886292 +86-19521323435 |
sales2@qschem-pharma.com | China | 202 | 58 |
Shanghai Yunao International Trade Co., Ltd | +8617621705551 |
asdf@shanghaihg.cn | China | 265 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11001 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 |
sales@alphabiopharm.com | China | 886 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9354 | 55 |