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Plecanatide

Plecanatide 구조식 이미지
카스 번호:
467426-54-6
상품명:
Plecanatide
동의어(영문):
Plecanatide;Prikanatide;Plecanatide impurity;Plecanatide fandachem;Plecanatide Impurtiy;Plecanatide USP/EP/BP;Prikanatide Plecanatide fandachem;ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4);L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)
CBNumber:
CB33164713
분자식:
C65H104N18O26S4
포뮬러 무게:
1681.89
MOL 파일:
467426-54-6.mol

Plecanatide 속성

끓는 점
2120.0±65.0 °C(Predicted)
밀도
1.47±0.1 g/cm3(Predicted)
산도 계수 (pKa)
3.61±0.21(Predicted)

안전

유해 물질 데이터 467426-54-6(Hazardous Substances Data)

Plecanatide C화학적 특성, 용도, 생산

용도

Plecanatide is used in the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. It works as a laxative by drawing water in to the gastrointestinal tract thereby softening stool and encouraging its natural passage.

효소 저해제

This uroguanylin analogue (FW = 1681.90 g/mol; CAS 467426-54-6), also known by the codename SP-304, binds to and activates guanylate cyclase-C (GC-C) receptors (EC50 ≈ 0.3 μM) expressed on the epithelial cells lining turn sequentially activates protein kinase G-II and the chloride channel known as the Cystic Fibrosis Transmembrane-conductance Regulator (CFTR) to regulate ion and fluid transport, to promote epithelial cell homeostasis, and to maintain barrier function in the GI mucosa. Plecanatide is a hexadecapeptide that is structurally identical to uroguanylin, except for an glutamate substitution at position-3. Oral treatment with plecanatide at a dose range between 0.05-2.5 mg/kg per day is as effective as once-daily treatment with 5-amino salicylic acid (100 mg/kg) or sulfasalazine (80 mg/kg). Amelioration of colitis by the treatment with plecanatide or dolcanatide was not dose-dependent, most likely due to saturation of available GC-C receptors.

Plecanatide 준비 용품 및 원자재

원자재

준비 용품


Plecanatide 공급 업체

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