디-터어트-뷰틸실릴 비스(트리플루오로메탄설포네이트)
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디-터어트-뷰틸실릴 비스(트리플루오로메탄설포네이트) 속성
- 끓는 점
- 73-75 °C/0.35 mmHg (lit.)
- 밀도
- 1.352 g/mL at 25 °C (lit.)
- 굴절률
- n
20/D 1.398(lit.)
- 인화점
- 195 °F
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 가장 일반적인 유기 용매인 Sol입니다.
- 물리적 상태
- 기름
- 색상
- 맑은 연한 노란색
- Specific Gravity
- 1.358
- Hydrolytic Sensitivity
- 8: reacts rapidly with moisture, water, protic solvents
- BRN
- 3569211
- 안정성
- 수분에 민감한
- InChIKey
- HUHKPYLEVGCJTG-UHFFFAOYSA-N
- CAS 데이터베이스
- 85272-31-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | C | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 34 | ||
| 안전지침서 | 26-36/37/39-45 | ||
| 유엔번호(UN No.) | UN 3265 8/PG 2 | ||
| WGK 독일 | 3 | ||
| F 고인화성물질 | 10-21 | ||
| 위험 참고 사항 | Corrosive | ||
| TSCA | No | ||
| 위험 등급 | 8 | ||
| 포장분류 | III | ||
| HS 번호 | 29319090 | ||
| 유해화학물질 필터링 | 2018-1-876(신규화학물질) | ||
| 함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 1,1,1-트리플루오로메탄술폰산 비스(1,1-디메틸에틸)[[(트리플루오로메틸) 술포닐]옥시]실릴 및 이를 5% 이상 함유한 혼합물 |
디-터어트-뷰틸실릴 비스(트리플루오로메탄설포네이트) C화학적 특성, 용도, 생산
화학적 성질
Colorless to yellow liquid물리적 성질
bp 73–75°C/0.35 mmHg; d 1.208 g cm?3.용도
Di-t-butylsilyl bis(trifluoromethanesulfonate) is a reagent for the selective protection of polyhydroxy compounds. This reagent reacts with 1,2-, 1,3-, and 1,4-diols under mild conditions to give the corresponding dialkylsilylene derivatives in high yield (0–50°C, 79–96%). Deprotection is conveniently achieved by using aqueous hydrofluoric acid in acetonitrile (eq 1).Unlike di-t-butyldichlorosilane, this reagent reacts with hindered alcohols. Even pinacol reacts to give the silylene derivative (100°C, 24 h, 70%). Di-t-butylsilylene derivatives of 1,2-diols are more reactive than those of 1,3- and 1,4-diols and undergo rapid hydrolysis (5 min) in THF/H2O at pH 10, while the 1,3- and 1,4- derivatives are unaffected at pH 4–10 (22°C) for several hours. This protecting group is stable under the conditions of PDC oxidation of alcohols (CH2Cl2, 25?C, 27 h) and tosylation of alcohols (pyridine, 25°C, 27 h).
The reagent has seen limited use for the protection of alcohols but has been used to protect nucleosides (eq 2).The procedure consists of sequential addition of the ditriflate and triethylamine to the nucleoside in DMF. The choice of solvent is critical.
제조 방법
by the treatment of di-t-butylchlorosilane with trifluoromethanesulfonic acid, followed by distillation (71% yield).디-터어트-뷰틸실릴 비스(트리플루오로메탄설포네이트) 준비 용품 및 원자재
원자재
준비 용품
디-터어트-뷰틸실릴 비스(트리플루오로메탄설포네이트) 공급 업체
글로벌( 190)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 |
sales@fluoropharm.com | China | 1290 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 6992 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 |
CHINA | 514 | 58 |