DOXACURIUM CHLORIDE

DOXACURIUM CHLORIDE 구조식 이미지
카스 번호:
106819-53-8
상품명:
DOXACURIUM CHLORIDE
동의어(영문):
Nuromax;Doxacurium;BW-A938U;DOXACURIUM CHLORIDE;DOXACURIUM CHLORIDE USP/EP/BP;bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride
CBNumber:
CB3366932
분자식:
C56H78Cl2N2O16
포뮬러 무게:
1106.13
MOL 파일:
106819-53-8.mol

DOXACURIUM CHLORIDE 속성

안전

DOXACURIUM CHLORIDE C화학적 특성, 용도, 생산

개요

Doxacurium chloride is an injectable, noncumulative, nondepolarizing neuromuscular blocking agent which exhibits no significant cardiovascular effects. It is a mixture of (lR, l′S, 2S, 2′R), (lR, l′R, 2S, 2′s) and (lS, l′S, 2R, 2′R) isomers of a bis-benzylisoquinolinium diester.Doxacurium chloride provides satisfactory intubation with duration of action similar to d-tubocurarine or pancuronium. However, it is reported to be 2 to 3 times as potent as pancuronium.

용도

Doxacurium Chloride is a nondepolarizing neuromuscular blocking agent that is minimally hydrolyzed by human plasma cholinesterase.

일반 설명

The molecular structure of doxacuriumchloride, 1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy2-methyl-1-(3,4,5-trimethoxybenzyl) isoquinoliniumchloride succinate (Nuromax), provides thepossibility for 10 stereoisomers: 4 d,l pairs and two mesoforms. Of the 10 stereoisomers, 3 are all-trans configuration,and these are the only active ones. Doxacurium chlorideis a long-acting nondepolarizing blocking agent. The drugdiffers from drugs such as gallium and pancuronium in thatit has no vagolytic activity. It is used as a skeletal musclerelaxant in surgical procedures expected to last longer than90 minutes.

Pharmacokinetics

Doxacurium is a mixture of three trans, trans-stereoisomers, a dl pair [(1R,1′R,2S,2′S) and (1S,1′S,2R,2′R)] and a meso form (1R,1′S,2S,2′R). Doxacurium is hydrophilic, has a small volume of distribution, and is distributed primarily to extracellular fluids. It is not metabolized by plasma cholinesterase or hepatic enzymes and does not undergo Hofmann elimination.

DOXACURIUM CHLORIDE 준비 용품 및 원자재

원자재

준비 용품


DOXACURIUM CHLORIDE 공급 업체

글로벌( 36)공급 업체
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Dideu Industries Group Limited
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AFINE CHEMICALS LIMITED
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Hangzhou MolCore BioPharmatech Co.,Ltd.
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Protheragen-ING
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info@protheragen-ing.com United States 528 58
Hubei jian chu biological technology co., LTD 027-027-65021350 18164064948
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