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글루코사민

글루코사민
글루코사민 구조식 이미지
카스 번호:
3416-24-8
한글명:
글루코사민
동의어(한글):
글루코사민
상품명:
Glucosamine
동의어(영문):
GLUCOSAMINE;aminoglucose;D-GLUCOSAMINE;D-(+)-Glucosamine hy;SYNTHETICGLUCOSAMINE;Propyl N-Acetyl-βGlucosamine USP/EP/BP;2-Amino-2-deoxyglucose;aldehydo-D-glucosamine;GlucosaMine(Feed grade)
CBNumber:
CB3414563
분자식:
C6H13NO5
포뮬러 무게:
179.17
MOL 파일:
3416-24-8.mol

글루코사민 속성

끓는 점
311.69°C (rough estimate)
밀도
1.3767 (rough estimate)
굴절률
1.4240 (estimate)
저장 조건
Keep in dark place,Sealed in dry,Room Temperature
산도 계수 (pKa)
pKa 8.04(H2O,t = 15.5,I=0.00,N2)(Approximate)
녹는점
88 °C
CAS 데이터베이스
3416-24-8(CAS DataBase Reference)
EPA
Glucosamine (3416-24-8)

안전

유해 물질 데이터 3416-24-8(Hazardous Substances Data)

글루코사민 C화학적 특성, 용도, 생산

개요

그것은 당뇨병의 영양 식품으로 코티솔 대신 장염을 치료할 수 있으며 류마티스 성 관절염과 B 형 간염에 대한 치료 효과가있어 항생제의 유효성을 촉진 할 수 있습니다. 항암 효과가 있으며 메소의 독성을 조절할 수있는 합성 된 새로운 수용성 약물은 흑색 종, 폐암 및 신장 암종에 치료 효과가있다. 게다가, 그것은 cosmetic.feed 및 식품 첨가물 산업에서 사용됩니다. 따라서 그것은 국제 시장에서 매우 인기가 있습니다.

용도

1. 글루코사민 설페이트는 항생제, 당뇨병을위한 영양 보충제의 역할의 효과를 증진 할 수 있습니다.
2. 그것은 신체의 점액 다당류 합성을 촉진하고 관절 윤활유의 점도를 향상시킬 수 있습니다.
3. 글루코사민 황산염은 대장염의 코티솔 치료제가 아니라 류마티스 관절염, B 형 간염 등의 치료에 사용됩니다.
4. 관절 연골의 신진 대사를 향상시켜 관절 연골 회복에 도움이되며 중한 항 염증성 진통 효과가 있습니다.
5. 항암제에 효과가 있으며, 작은 특성, 흑색 종, 폐암, 신장 암 등의 골수 독성을 억제합니다.
 

포장, 보관 및 운송

저장 시원하고 건조하며 깨끗한 곳에서.유통 기한2 년.

화학적 성질

(β form.) Colorless needles. Mp 110C (decomposes). Very soluble in water; slightly soluble in methanol and ethanol; insoluble in ether and chloroform.

출처

Glucosamine is found in mucopolysaccharides, chitin, and mucoproteins. Glucosamine is a naturally occurring substance; glucosamine sulfate is manufactured synthetically.

용도

Pharmaceutic aid.

정의

ChEBI: The open-chain form of D-glucosamine.

상표명

Adaxil;Antatril;Arthryl;Chitosamine;Corti-anartril;Dona 200-s;Dona compositum;Donna 200;Pona;Terramycin;Terrastatom;Tetracyn;Thiocondramine;Viartril.

World Health Organization (WHO)

Glucosamine is found in chitin, mucoproteins and mucopolysaccharides. It is used as a pharmaceutical aid. Glucosamine sulfate has been used in the treatment of rheumatic disorders though it is not widely marketed for this purpose.

Veterinary Drugs and Treatments

These compounds may be useful in treating osteoarthritis or other painful conditions in domestic animals, but large, well-designed controlled clinical studies proving efficacy were not located. One study in dogs (McCarthy, O’Donovan et al. 2007) showed some positive effect, but this study was not placebo controlled and compared responses versus carprofen. Another placebo-controlled, blinded study in dogs (Moreau, Dupuis et al. 2003), did not demonstrate statistically significant improvement after 60 days of treatment.
These compounds potentially could be of benefit in cats with FLUTD (feline lower urinary tract disease) because of the presence of glycosaminoglycans as part of the protective layer of the urinary tract. Controlled studies have shown some positive effects in some cats, but overall did not appear to make a significant difference.

Purification Methods

Crystallise the amines from MeOH. The free base has been obtained from the hydrochloride (21.5g, see below) in a mixture of Et3N (15mL) and EtOH (125mL) by shaking for 2days at room temperature, and the solid Et3N.HCl is filtered off and the process repeated with more Et3N (3-4 times) until the D-glucosamine (15g) is free from Cl ions. It has m 88o , [] D20 +100o mutarotating to +47.5o (c 1, H2O). When Et2NH is used as base, the  to  conversion is complete giving D-glucosamine. The pentaacetate is purified by dissolving in CHCl3, treating with charcoal, drying (MgSO4), evaporating the solvent, and adding a little dry Et2O to induce crystallisation. It has m 124-126o, [] D +113o (c 1, CHCl3) after 16hours in a desiccator. [Leaback Biochemical Preparations 10 118 1963.] The N-acetyl derivative, m 203-205o from MeOH/Et2O (dry in vacuum P2O5) has [] D +75o to +41o (c 2, H2O); this derivative can also be purified by dissolving in the minimum volume of H2O to which is added 7-8volumes of EtOH followed by Et2O until turbid and keeping at ~20o to crystallise. Wash the crystals with MeOH then Et2O and dry in vacuo over P2O5. [Horton Biochemical Preparations 11 1 1966.]

글루코사민 준비 용품 및 원자재

원자재

준비 용품


글루코사민 공급 업체

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