Midazolam
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Midazolam 속성
- 녹는점
- 161-164°C
- 끓는 점
- 496.9±55.0 °C(Predicted)
- 밀도
- 1.3136 (estimate)
- 인화점
- 9 °C
- 저장 조건
- Controlled Substance, -20°C Freezer
- 용해도
- 물에는 거의 녹지 않으며, 아세톤과 에탄올(96%)에는 잘 녹고, 메탄올에는 녹습니다.
- 물리적 상태
- Solid:crystalline
- 산도 계수 (pKa)
- pKa 1.7±0.1;6.15± 0.1 (Uncertain)
- 수용성
- 54mg/L(24℃)
- BCS Class
- 1
- LogP
- 2.73
- CAS 데이터베이스
- 59467-70-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | F,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 11-23/24/25-39/23/24/25 | ||
| 안전지침서 | 7-16-36/37-45 | ||
| 유엔번호(UN No.) | 3249 | ||
| WGK 독일 | 2 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 2933910000 | ||
| 유해 물질 데이터 | 59467-70-8(Hazardous Substances Data) | ||
| DEA Controlled Substances | CSCN: 2884 CAS SCH: IV NARC: N |
Midazolam C화학적 특성, 용도, 생산
개요
Midazolam is the most commonly used parenteral sedative in anaesthetic practice. The structure of midazolam is altered by local changes in pH (tautomerism), and the two different forms confer either water or lipid solubility to the drug . At pH<4 the benzodiazepine nucleus opens because of an ionisable amine group in the molecule's structure, and this increases water solubility. At plasma pH the amine group is incorporated back into the unionised ring form of the molecule, which is highly lipid soluble and diffuses rapidly into the brain. A concentrated preparation (5mgml ?1 ) is available for i.m. injection and absorption is rapid compared with diazepam.화학적 성질
White Crystaline Solid용도
In many countries this product is controlled. An import permit may be required. Anesthetic; anticonvulsant; sedative; hypnotic일반 설명
Midazolam is a benzodiazepine, sold as Dormicum, Hypnovel?, and Versed as a sedative and treatment for insomnia and seizures. This Snap-N-Spike? Reference Solution is suitable for many GC/MS or LC/MS applications from clinical toxicology and urine drug testing to pain prescription monitoring or forensic analysis.Pharmacokinetics
Midazolam undergoes hepatic oxidative metabolism and has an elimination half-life of 2–4h. The major metabolite is 1-hydroxymidazolam, which is biologically active. Midazolam has been used as a sole hypnotic for TI VA and produces superior procedural amnesia compared with propofol, but CSHT increases significantly when used by continuous infusion, and this delays recovery. Clinical studies demonstrate the inferiority of midazolam in terms of time to onset of desired sedation score, slower recovery, less clear-headedness, and significantly longer period of postoperative amnesia compared with propofol.Midazolam 준비 용품 및 원자재
원자재
5-(2-chloroethyl)-2,3-dihydrobenzofuran
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-3-[(4-methylphenyl)sulfonyl]-
8-chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid
8-CHLORO-3A,4-DIHYDRO-6-(2-FLUOROPHENYL)-1-METHYL-3H-IMIDAZO[1,5-A][1,4]BENZO-DIAZEPINE
Midazolam EP Impurity J
N-desalkylflurazepam
요오드 메탄
말레인산