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이미다졸리다이닐우레아

이미다졸리다이닐우레아
이미다졸리다이닐우레아 구조식 이미지
카스 번호:
39236-46-9
한글명:
이미다졸리다이닐우레아
동의어(한글):
이미다졸리다이닐우레아;이미다졸리디닐우레아
상품명:
N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea
동의어(영문):
IMIDUREA;Sept 115;germall115;Tristat 1U;Euxyl K 200;Biopure 100;Imidurea NF;Unicide U-13;Imidurea (200 mg);Imidazolidnyl UREA
CBNumber:
CB3426267
분자식:
C11H16N8O8
포뮬러 무게:
388.29
MOL 파일:
39236-46-9.mol

이미다졸리다이닐우레아 속성

녹는점
141-143℃
끓는 점
514.04°C (rough estimate)
밀도
1.4245 (rough estimate)
굴절률
1.6910 (estimate)
저장 조건
2-8°C
용해도
Soluble in water and in glycerol, but insoluble in almost all organic solvents.
산도 계수 (pKa)
7.41±0.10(Predicted)
물리적 상태
Liquid
색상
Clear
수용성
soluble
Merck
14,4916
안정성
Stable.
InChIKey
ZCTXEAQXZGPWFG-UHFFFAOYSA-N
CAS 데이터베이스
39236-46-9(CAS DataBase Reference)
EPA
Imidurea (39236-46-9)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36
안전지침서 26-36
WGK 독일 2
RTECS 번호 YT7365000
TSCA Yes
HS 번호 29332990
기존화학 물질 KE-23828
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P337+P313 눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

이미다졸리다이닐우레아 MSDS


N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea

이미다졸리다이닐우레아 C화학적 특성, 용도, 생산

개요

Imidazolidinyl urea, a formaldehyde releaser, is mainly contained in cosmetics and liquid soaps.

화학적 성질

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is solid with a mild odour

화학적 성질

Imidurea is a white, free-flowing odorless powder.

용도

imidazolidinyl urea is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential. In 2010, it was the tenth most frequently used preservative in the united States (parabens ranged from first to sixth place). generally, imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity. Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions, there is no detection of free formaldehyde release. of all the formaldehydereleasing preservatives, imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions.

용도

Antimicrobial

용도

Antimicrobial preservative in cosmetics and topical pharmaceutical preparations.

생산 방법

Imidurea is produced by the condensation of allantoin with formaldehyde.

Pharmaceutical Applications

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is a broad-spectrum antimicrobial preservative used in cosmetics and topical pharmaceutical formulations; typical concentrations used are 0.03–0.5% w/w. It is effective between pH 3–9 and is reported to have synergistic effects when used with parabens.

색상 색인 번호

Imidazolidinyl urea, a formaldehyde releaser related to diazolidinyl urea (see above), is used as an antimicrobial agent very active against Gram-positive and Gram-negative bacteria, used as a synergist in combination with para- bens. It is used as a preservative in aqueous products, mainly in cosmetics, toiletries, and liquid soaps.

Safety

Imidurea is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. However, there have been some reports of contact dermatitis associated with imidurea, although these are relatively few considering its widespread use in cosmetics. Although imidurea releases formaldehyde, it does not appear to be associated with cross-sensitization with formaldehyde or other formaldehyde-releasing compounds.
LD50 (mouse, oral): 7.2 g/kg
LD50 (rabbit, skin): > 8 g/kg
LD50 (rat, oral): 11.3 g/kg

저장

Imidurea is hygroscopic and should be stored in a well-closed container in a cool, dry place.

비 호환성

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is incompatible with strong oxidants. It is compatible with other preservatives including sorbic acid and quaternary ammonium compounds. It is also compatible with other pharmaceutical and cosmetic excipients including proteins, nonionic surfactants, and lecithin.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical preparations). Accepted for use in cosmetics in Europe and the USA. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

이미다졸리다이닐우레아 준비 용품 및 원자재

원자재

준비 용품


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