5-플루오로-2-옥신돌
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5-플루오로-2-옥신돌 속성
- 녹는점
- 143-147 °C (lit.)
- 끓는 점
- 307.2±42.0 °C(Predicted)
- 밀도
- 1.311±0.06 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 분말 또는 결정성 분말
- 산도 계수 (pKa)
- 12.99±0.20(Predicted)
- 색상
- 흰색에서 옅은 갈색까지
- InChI
- InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
- InChIKey
- DDIIYGHHUMKDGI-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(F)C=C2)CC1=O
- CAS 데이터베이스
- 56341-41-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,C | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-34 | ||
안전지침서 | 22-24/25-45-36/37/39-27-26 | ||
WGK 독일 | 3 | ||
위험 참고 사항 | Irritant/Keep Cold | ||
위험 등급 | IRRITANT, KEEP COLD | ||
HS 번호 | 29339900 |
5-플루오로-2-옥신돌 C화학적 특성, 용도, 생산
화학적 성질
Light Yellow Crystalline용도
5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.주요 응용
5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors.제조 방법
synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%.생물학적 활성
5-Fluoro-2-oxindole has anti-inflammatory, antioxidant, anxiolytic, antidepressant and antinociceptive effects and inhibits neuropathic pain. Treatment with 5-Fluoro-2-oxindole increased the expression of NQO1, HO-1, and MOR in the spinal cord and/or paw and inhibited CFA-induced up-regulation of phosphorylated MAPK, 4-HNE, NOS2, CD11b/c, and IBA-1. 5-Fluoro-2-oxindole ameliorated the local effects of morphine. Studies have revealed that 5-fluoro-2-oxindole inhibits plasticity, oxidative and inflammatory responses induced by peripheral inflammation and enhances the antinociceptive effects of morphine. Thus, the use of 5-fluoro-2-indole alone and/or in combination with morphine are two remarkable new approaches for the treatment of chronic inflammatory pain.5-플루오로-2-옥신돌 준비 용품 및 원자재
원자재
디플로로니트로벤젠(2,4-)
수소화나트륨
말론산 디메틸
다이메틸 설폭사이드
철분
염화 리튬
1-하이드록시-3H-인돌-2-온
Ethyl iodoacetate
4-플루오로이소니트로소아세트아닐리드
5-플루오로-3-히드라조노인돌린-2-온
2-(2-aMino-5-플루오로페닐)아세토히드라지드
(5-FLUORO-2-NITRO-PHENYL)-아세트산
벤젠아세트산,5-플루오로-2-니트로-,메틸에스테르
5-플루오로이사틴
4-플루오로아세트아닐리드
메틸티오아세트산에틸에스테르
터르트-부틸 하이포클로라이트
준비 용품
5-플루오로-2-옥신돌 공급 업체
글로벌( 607)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 |
sales@allfluoro.com | China | 5791 | 58 |
Senova Technology Co. Ltd. | +86-0755-86703119 +8618503098836 |
info@senovatech.com | China | 351 | 58 |
Shanghai QiXin New Materials Technology Co.,Ltd | +8615116235351 |
derrickguo@sh-qixin.cn | China | 16 | 58 |
Golden Pharma Co., Limited | +undefined18958062155 |
sales@zjgoldpharm.com | China | 5905 | 58 |
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD | +8618291886785 |
olivia.wang@pushanshiye.com | China | 164 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20293 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 |
sales8@hbganmiao.com | China | 300 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |