ChemicalBook >제품 카탈로그 >API>순환계 약물>항 고혈압제>5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole 구조식 이미지

카스 번호:: 124750-53-4

상품명:: 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

동의어(영문):: TTMB;ENTERPRISESTANDARD;Losartan Impurity 9;Olmesartan TTMB impurity;5-[2-(4-methylphenyl)phenyl]-1-trityltetrazole;5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole;5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole;Olmesartan Medoxomil Impurity 24（Losartan Impurity 9）;N-(TRIPHENYLMETHYL)-5-(4'-METHYLBIPHENYL-2-YL)TETRAZOLE;n-(triphenylmethyl)-5-(4'-methylbiphenyl-2-yl-)terazole

CBNumber:: CB3438158

분자식:: C33H26N4

포뮬러 무게:: 478.59

MOL 파일:: 124750-53-4.mol

속성

안전

용도

공급 업체 171

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole 속성

녹는점: 166-169 °C(Solv: ethyl acetate (141-78-6); dichloromethane (75-09-2))

끓는 점: 681.6±65.0 °C(Predicted)

밀도: 1.13±0.1 g/cm3(Predicted)

저장 조건: Inert atmosphere,Room Temperature

용해도: 클로로포름(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 0.30±0.10(Predicted)

색상: 회백색

CAS 데이터베이스: 124750-53-4(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P271	옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P304+P340	흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P312	불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P403+P233	용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole C화학적 특성, 용도, 생산

화학적 성질

Off-white Solid

용도

An intermediate in the preparation of labelled Candesartan.

Synthesis

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole is prepared by the reaction of trityl chloride and 2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl. The specific synthesis steps are as follows:
Dissolve compound 2 (200 g) with stirring at 40°C 700mL of acetone, Aqueous sodium hydroxide solution (40.67 g sodium hydroxide dissolved in 160 mL water) is added, Continue stirring for 1h, A solution of triphenylchloromethane in acetone (270.8 g of triphenylmethyl chloride dissolved in 800 mL of acetone) was initially added dropwise. The solid was added dropwise and gradually evolved into a white turbid liquid. The reaction was monitored by TLC until it was completely filtered off and washed with water to give a solid as intermediate 3. The solid was blow dried at 50°C to give white intermediate 3 (385 g), yield: 95.2%, HPLC: 99.44%.

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole 준비 용품 및 원자재

원자재

준비 용품

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole 공급 업체

글로벌( 171)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12477	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole 관련 검색:

트리틸클로라이드 염화 2,3,5-트리페닐 테트라졸륨 메틸 페닐 실로산과 실리콘 Trityl candesartan Trityl Irbesartan Trityl candesartan cilexetil 4,4'-Dimethylbiphenyl Chlorodimethylphenylsilane Trityl olmesartan 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole 2-Butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-2-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole 4-Phenyltoluene methylphenyl silicone resin Benzyl N-[(2(Trityltetrazol-5-yl-1,1biphenyl-4-yl]-methyl-2-amino-3-methylbutanoate 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole AKOS 91708 AKOS 91707