Aminoacylase
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Aminoacylase 속성
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
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위험 카페고리 넘버 | 36/37/38-42 | ||
안전지침서 | 22-24/25-36/37-26-24 | ||
WGK 독일 | 3 | ||
RTECS 번호 | BF4890000 | ||
F 고인화성물질 | 3-10-21 | ||
HS 번호 | 35079090 |
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신호 어: | Danger | |||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Aminoacylase C화학적 특성, 용도, 생산
개요
Aminoacylase-1 (EC 3.5.1.14) is a homodimeric zinc-binding metalloenzyme. A cytosolic enzyme with a wide range of tissue expression, it cleaves acylated L-amino acids (except L-aspartate) into L-amino acids and an acyl group. L-aspartate derivatives are cleaved by aminoacylase-2 (aspartoacylase). Aminoacylase-1 is the most abundant of the aminoacylases, a class of enzymes involved in hydrolysis of N-acetylated proteins.용도
Acylase I from porcine kidney has been used to study the acylase I-catalyzed deacetylation of various S-alkyl-N-acetyl-L-cysteines and their carbon and oxygen analogues . Acylase I may be useful to catalyze N-acetyl amino acids to enantiomerically pure L-amino acids .주요 응용
Acylase I from porcine kidney has been used to study the acylase I-catalyzed deacetylation of various S-alkyl-N-acetyl-L-cysteines and their carbon and oxygen analogues . Acylase I may be useful to catalyze N-acetyl amino acids to enantiomerically pure L-amino acids.Biological Functions
Aminoacylases (N-acyl-L-amino acid amidohydrolases; EC 3.5.1.14) are widely found in animals, plants and microorganisms. The primary function of these enzymes is to remove acyl residues from N-acetylated amino acids although they may also be capable of hydrolysing carboxylic acid amides to fatty acid anions and L-amino acids. Although the catalytic mechanism of aminoacylases has been known for decades, the physiological role of these enzymes is still poorly understood. Activities of a similar nature, however, have been found in certain carboxypeptidases, aminopeptidases and dipeptidases. It could be therefore suggested that aminoacylases have a role to play in protein/peptide turnover.일반 설명
Acylase I belongs to the aminoacylase family of enzymes.효소 저해제
Aminoacylase is a metallo-enzyme that needs Zinc (Zn2+) as a cofactor to function. The Zinc ions inside of aminoacylase are each coordinated to histidine, glutamate, aspartate, and water. The Zinc ion polarizes the water, facilitating its deprotonation by a nearby basic residue. The negatively charged hydroxide ion is nucleophilic and attacks the electrophilic carbonyl carbon of the substrate's acyl group.The exact mechanism after this point is unknown, with one possibility being that the carbonyl then reforms, breaks the amide bond, and forms the two products. At some point in the mechanism, another water molecule enters and coordinates with Zinc, returning the enzyme to its original state.The nucleophilic attack by water is the rate-limiting step of aminoacylase's catalytic mechanism. This nucleophilic attack is reversible while the subsequent steps are fast and irreversible. This reaction sequence is an example of Michaelis–Menten kinetics, allowing one to determine KM, Kcat, Vmax, turnover number, and substrate specificity through classic Michaelis-Menten enzyme experiments. The second and third forward steps cause the formation and release of the reaction's products.
Aminoacylase 준비 용품 및 원자재
원자재
준비 용품
Aminoacylase 공급 업체
글로벌( 140)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Creative Enzymes | 1-516-855-7709 |
info@creative-enzymes.com | United States | 8748 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 |
sales@myuchem.com | China | 6711 | 58 |
Henan Alfa Chemical Co., Ltd | +8618339805032 |
alfa4@alfachem.cn | China | 12755 | 58 |
Ningxia LabsChem Co., Ltd. | 0952-9294929 +8613895679378 |
48472788@qq.com | China | 352 | 58 |
Shanghai Innopharm Industrial Co., Ltd. | +86-21-59960785 +86-17701845089 |
sales@hoyaopharm.com | China | 261 | 58 |
Hebei Duling International Trade Co. LTD | +8618032673083 |
sales05@hbduling.cn | China | 15747 | 58 |
Aminoacylase 관련 검색:
알루미늄 아세틸아세토네이트 코발트(II) 아세틸아세토네이트 하이드레이트 실버 아세틸아세토네이트 디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트) 아세틸아세톤산 구리 아세틸아세토산 제2철
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
Ethyl isocyanoacetate
SALCOMINE
TERT-BUTYL ISOCYANIDE
Tosylmethyl isocyanide
METHYL ISOCYANOACETATE
PHENYLSELENOL
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
Tris(2,4-pentanedionato)chroMiuM(III)
N-BUTYLISOCYANIDE
Benzyl isocyanide
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)