DEMECOLCINE
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DEMECOLCINE 속성
- 녹는점
- 73-75°C
- 알파
- D20 -129.0° (c = 1 in chloroform)
- 끓는 점
- 501.11°C (rough estimate)
- 밀도
- 1.2350 (rough estimate)
- 굴절률
- 1.5614 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 10mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 8.48±0.40(Predicted)
- 감도
- Air & Light Sensitive
- BRN
- 2822892
- 안정성
- 흡습성
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,T+ | ||
---|---|---|---|
위험 카페고리 넘버 | 25-26/27/28 | ||
안전지침서 | 22-24/25-45-36/37/39 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | GH0800000 | ||
F 고인화성물질 | 8-10-23 | ||
위험 등급 | 6.1(a) | ||
포장분류 | II | ||
독성 | LD50 oral in mouse: 25530ug/kg |
DEMECOLCINE C화학적 특성, 용도, 생산
개요
Colcemid is a colchicine derivative that inhibits tubulin polymerization as potently as colchicine (IC50 = 2.1 and 2.4 μM, respectively) but is less toxic. At very low (nanomolar) concentrations, colcemid suppresses microtubule dynamicity and inhibits cell migration, while at micromolar levels it blocks microtubule assembly, arresting cells in metaphase. Mitotic block by colcemid is used to synchronize cells and for karyotyping in cytogenetic studies. Prolonged exposure to colcemid can activate p53, leading to apoptosis.화학적 성질
Faintly Yellow Crystalline Powder용도
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.정의
ChEBI: A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than olchicine and is used as an antineoplastic.일반 설명
Colcemid is also known as demecolcine. Its generic name is N-methyl-N-deacetyl-colchicine. Colcemid depolymerizes microtubules and blocks mitosis at metaphase.Safety Profile
Poison by ingestion, intraperitoneal, parenteral, intravenous, and intramuscular routes. Human systemic effects by ingestion: (skin and appendages) hair effects. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.Purification Methods
Colcemide is purified by chromatography on silica and eluting with CHCl3/MeOH (9:1), and by recrystallisation from EtOAc/Et2O to form yellow prisms. UV in EtOH has max 243nm ( 30,200) and 350nm ( 16,3000). [Synthesis, IR, NMR, MS: Capraro & Brossi Helv Chim Acta 62 965 1979, Beilstein 8 IV 3319.]DEMECOLCINE 준비 용품 및 원자재
원자재
준비 용품
DEMECOLCINE 공급 업체
글로벌( 127)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7786 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 |
1015@dideu.com | China | 2263 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Wuhan Monad Medicine Tech Co.,LTD | 02768782018 18771942761 |
sales01@whmonad.com | CHINA | 992 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29271 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 49999 | 58 |
DEMECOLCINE 관련 검색:
GLORIOSINE
Colchicine
COLCHICOSIDE
DEMECOLCINE
COLCHICINE, [RING C, METHOXY-14C]
COLCHICINE, [RING C, METHOXY-3H]
N-(2-MERCAPTOETHYL) DEMECOLCINE
N-TRIFLUOROACETYL DEACETYLCOLCHICINE
N-TRIFLUOROACETYL-N-METHYL-DEACETYLCOLCHICINE
COLCHICINE METHANETHIOSULFONATE
COLCHICINE-D3
DEMECOLCINE HYDROGEN BROMIDE SALT
COLCHICINE-D6
DEMECOLCINE-D3
DEMECOLCINE-D6
(S)-7-[(2-HYDROXY-BENZYL)-METHYL-AMINO]-1,2,3,10-TETRAMETHOXY-6,7-DIHYDRO-5H-BENZO[A]HEPTALEN-9-ONE
COLCHICINE SALICYLATE
DEMECOLCIN-D3