FMOC-LYS(BOC)(ME)-OH

FMOC-LYS(BOC)(ME)-OH 구조식 이미지
카스 번호:
951695-85-5
상품명:
FMOC-LYS(BOC)(ME)-OH
동의어(영문):
Fmoc-Lys(Me,Boc);FMOC-LYS(ME,BOC)-OH;FMOC-LYS(BOC)(ME)-OH;FMOC-L-LYS(BOC, ME)-OH;Boc-L-Lys(Fmoc)(Me)-OH;FMOC-LYSINE(BOC)(ME)-OH;Fmoc-Lys(Me,Boc)-OH,95%;Fmoc-Lys(Me,Boc)-OH, >=97%;FMOC-LYS(BOC)(ME)-OH USP/EP/BP;Fmoc-Lys(Me,Boc)-OH Novabiochem
CBNumber:
CB3465262
분자식:
C27H34N2O6
포뮬러 무게:
482.57
MOL 파일:
951695-85-5.mol

FMOC-LYS(BOC)(ME)-OH 속성

녹는점
85-87℃
끓는 점
665.4±55.0 °C(Predicted)
밀도
1.200
저장 조건
-20°C
용해도
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
물리적 상태
가루
산도 계수 (pKa)
3.88±0.21(Predicted)
InChIKey
JHMSFOFHTAYQLS-QHCPKHFHSA-N
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
WGK 독일 WGK 2 water endangering
HS 번호 2924 29 70
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P271 옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.

FMOC-LYS(BOC)(ME)-OH C화학적 특성, 용도, 생산

개요

Fmoc-lys (BOC) (ME)-OH is a kind of protected form of lysine. Lysine is double-protected by butyloxycarbonyl (BOC) and 9H-fluoren-9-ylmethoxycarbon (FMOC). It is a derivative for the introduction of monomethyl-lysine during Fmoc SPPS. Coupling can be carried out using any standard activation method. The Boc protecting group can be removed through the TFA-mediated cleavage reaction. As a kind of protected amino acid, it is an important intermediate in various fields such as peptide synthesis, asymmetric synthesis, medicinal chemistry as well as polymer chemistry.

용도

  1. Heterochromatin protein 1 (HP1) depends on trimethylation of H3 Lys 9; aggregation of chromatines depends on Lys methylation
  2. Fmoc-Lys(Boc, Me)-OH is useful for preparing monomethylated histone fragments utilized in studying the regulatory roles of methylated histones. Fmoc-Lys(Boc,Me)-OH can be coupled using standard activating procedures. The Boc group on the side epsilon nitrogen atom is removed with TFA, usually at the same time as the peptide is cleaved from the resin.
  3. Fmoc-Lys(Boc, Me)-OH is a novel derivative for the introduction of monomethyl-lysine during Fmoc SPPS. Coupling can be carried out using any standard activation method. Removal of the Boc protecting group occurs during the course of the TFA-mediated cleavage reaction.

일반 설명

Fmoc protected N-methylated lysine

참고 문헌

http://www.chempep.com/ChemPep_Products2_Fmoc-Amino-Acid_Fmoc-Lys_Boc_Me_-OH.htm
https://en.wikipedia.org/wiki/Peptide_synthesis
Tung, C. L., et al. "A fluorogenic probe for recognizing 5-hydroxylysine inspired by serine/threonine ligation. " Chemical Communications 50.40(2014):5298-300.

FMOC-LYS(BOC)(ME)-OH 준비 용품 및 원자재

원자재

준비 용품


FMOC-LYS(BOC)(ME)-OH 공급 업체

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