Isoxepac
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Isoxepac 속성
- 녹는점
- 130-132°C
- 끓는 점
- 528.2±50.0 °C(Predicted)
- 밀도
- 1.39 g/cm3
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 메탄올에 용해됨
- 산도 계수 (pKa)
- 4.24±0.10(Predicted)
- 색상
- White to Light yellow to Light orange
- Merck
- 14,5237
- InChIKey
- QFGMXJOBTNZHEL-UHFFFAOYSA-N
- CAS 데이터베이스
- 55453-87-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25-62 | ||
| 안전지침서 | 36/37-45 | ||
| 유엔번호(UN No.) | UN 2811 6.1 / PGIII | ||
| RTECS 번호 | HQ4110000 | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | III | ||
| HS 번호 | 2932996560 | ||
| 독성 | LD50 orally in rats: 199 mg/kg (Ueno) |
| 그림문자(GHS): |
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| 신호 어: | Danger | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Isoxepac C화학적 특성, 용도, 생산
화학적 성질
Beige Solid용도
Isoxepac is a non-steroidal anti-inflammatory with analgesic and antipyretic activity. It is more slowly absorbed and eliminated in the rat and rabbit after oral dosing than in the dog, rhesus monkey and man.It can be used to treat allergic rhinitis, urticaria, and skin diseases with itching symptoms.제조 방법
Isoxic acid is an important intermediate in the synthesis of the new preferred anti-allergic drug, olopatadine hydrochloride, preparation method of isoxepac:(1) condensation: prepare p-hydroxyphenylaceticacid 8-12 part, phthalide 6-12 part, sodium methylate 8-12 part by weight; Dissolve with DMAC and to add said sodium methylate behind said p-hydroxyphenylaceticacid and the phthalide; Be that 0.1-10Pa is heated to 80-170 ℃ of reaction 3-10h at pressure then; Regulate the pH value to 1-5,4-(2-carboxyl benzyloxy) toluylic acid is separated out in crystallization;
(2) cyclization: with Glacial acetic acid min. 99.5 dissolving step (1) gained 4-(2-carboxyl benzyloxy) toluylic acid, adding 3-52 weight part polyphosphoric acid again, is that 0.1-10Pa is heated to 30-100 ℃ of reaction 3-12h at pressure, and crystallisation by cooling gets the Isoxepac bullion then;
(3) purify: behind the said Isoxepac bullion of acetic acid ethyl dissolution, refining decolouring gets the Isoxepac product.
https://patents.google.com/patent/CN102838582A/en
정의
ChEBI: Isoxepac is a dibenzooxazepine.상표명
Artil(Hoechst-Roussel) .Isoxepac 준비 용품 및 원자재
원자재
준비 용품
Isoxepac 공급 업체
글로벌( 356)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 |
sales001@rokechem.com | China | 255 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5964 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |