NSC73306 C화학적 특성, 용도, 생산
용도
(3Z)-1H-Indole-2,3-dione 3-[N-(4-Methoxyphenyl )thiosemicarbazone is a compound involved in the design and synthesis of novel anticancer agents that have the potential to overcome multidrug resistance.
Biochem/physiol Actions
NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells. Irrespective of variations in cell line background, NSC73306 consistently demonstrated a Pgp-potentiated MDR-selective toxicity. It appears that NSC73306 is transported into the cell by copper transporter 1 (CTR1, SLC31A1). It is not P-gp inhibitor.
NSC73306 준비 용품 및 원자재
원자재
준비 용품
