CHAETOMIUMMINUTUM의키토신
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CHAETOMIUMMINUTUM의키토신 속성
- 밀도
- 1.87±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO(최대 25mg/ml) 또는 에탄올(최대 25mg/ml)에 용해됩니다.
- 물리적 상태
- 흰색에서 회백색 고체
- 산도 계수 (pKa)
- 12.39±0.10(Predicted)
- 색상
- 하얀색
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.
- InChIKey
- PZPPOCZWRGNKIR-PNVYSBBASA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 20/21/22 | ||
유엔번호(UN No.) | 1544 | ||
WGK 독일 | 3 | ||
RTECS 번호 | FM3032000 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29419090 |
CHAETOMIUMMINUTUM의키토신 C화학적 특성, 용도, 생산
개요
Chaetocin (28097-69-1) is an antimicrobial fungal metabolite. It was found to be a specific inhibitor of the lysine-specific histone methyltransferase SU(VAR)3-9 (IC50 = 0.6 mM) of Drosophila melanogaster and of its human ortholog (IC50 = 0.8 mM). It acts as a competitive inhibitor for S-adenosylmethionine. The specificity of chaetocin for SU(VAR)3-9 makes this compound an excellent tool for the study of heterochromatin-mediated gene repression. Chaetocin has an antimyeloma activity which has been linked to induction of oxidative stress and subsequent apoptosis.화학적 성질
Chaetocin is supplied as a crystalline solid. A stock solution may be made by dissolving the chaetocin in the solvent of choice, which should be purged with an inert gas. Chaetocin is soluble in organic solvents such as DMSO. The solubility of chaetocin in DMSO is approximately 25 mg/ml.용도
Chaetocin is an epithiodioxopiperazine antibiotic that has recently shown promise as a selective antitumour agent. Chaetocin is an inhibitor of lysine-specific methyltransferase SU(VAR)3-9 both in vitro and in vivo. Chaetocin is dramatically accumulated in cancer cells via a process inhibited by glutathione. Inside the cell, its activity is mediated by the imposition of oxidative stress.주요 응용
Chaetocin is a natural metabolite isolated from Chaetomium minutum. It is a nonspecific inhbitor of histone lysine methyltransferases which are important epigenetic enzymes . Induces apoptosis in myeloma cell lines and exhibits antiproliferative activity in mammals. Chaetocin from Chaetomium minutum has been used to determine its effects on sensitization of various cells. It has also been used to determine the biological functions of OS-induced heterochromatin formation.일반 설명
Chaetocin is a fungal metabolite with antimicrobial and cytostatic activity. It belongs to the 3,6-epidithio-diketopiperazines class of which gliotoxin, sporidesmin, aranotin, oryzachloride, verticillin A and the melinacidins are members. Chaetocin is a molecular dimer of two five-membered rings cis fused. Interestingly, the chirality of the 3,6-epidithiodioxopiperazine moiety in chaetocin is opposite to the chirality of gliotoxin, sporidesmin, aranotin, and oryzachloride. Unlike these compounds, chaetocin does not have an antiviral activity. This fungal toxin showed strong cytotoxicity against HeLa cells (IC50 = 0.05 mg/ml).Biochem/physiol Actions
Chaetocin is a competitive inhibitor for S-adenosylmethionine. The specificity of chaetocin for SU(VAR)3-9 makes this compound an excellent tool for the study of heterochromatin-mediated gene repression.CHAETOMIUMMINUTUM의키토신 준비 용품 및 원자재
원자재
준비 용품
CHAETOMIUMMINUTUM의키토신 공급 업체
글로벌( 94)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29823 | 58 |
Aktin Chemicals, Inc. | 028-85159085 |
info@aktinchem.com | CHINA | 1025 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24099 | 58 |
BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 |
sales006@ingredients-lonier.com | China | 2605 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
CHAETOMIUMMINUTUM의키토신 관련 검색:
헥산디티올(1,-6) 2,5-디메틸피페라진
Forskolin
PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]-
SARCOSINE ANHYDRIDE
D-Prolinamide
1-Methylpiperazin-2-one
ISOPROPYL DISULFIDE
(S)-(+)-1-METHYL-3-PHENYLPROPYLAMINE
(1,4-DIMETHYL-2-PIPERAZINYL)METHANOL
(R)-(-)-2-Methylpiperazine
(R)-(+)-2-AMINOMETHYL-1-ETHYLPYRROLIDINE
1H-Indol-2-amine
3,4-DIMETHYL-3,4-DIPHENYLHEXANE
2,2'-ETHYLENEDIANILINE
N,N'-DIACETYL-1,6-DIAMINOHEXANE
hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one
3-BENZYLPYRROLIDINE