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R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST

R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST 구조식 이미지
카스 번호:
125-58-6
상품명:
R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST
동의어(영문):
levothyl;l-polamivet;(R)-Methadone;(-)-Diaminone;Laevomethadon;levomethadone;(6r)-methadone;4-diphenyl-6-(dimethylamino)-l-3-heptanon;4-diphenyl-6-(dimethylamino)-(r)-3-hetpanon;l-6-(dimethylamino)-4,4-diphenyl-3-heptanone
CBNumber:
CB3498242
분자식:
C21H27NO
포뮬러 무게:
309.44518
MOL 파일:
125-58-6.mol

R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST 속성

녹는점
99°C
끓는 점
449.71°C (rough estimate)
밀도
1.0350 (rough estimate)
굴절률
1.5614 (estimate)

안전

R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST C화학적 특성, 용도, 생산

Purification Methods

This pharmacologically active (against narcotic addiction) enantiomer was obtained by optical resolution (using D-tartaric acid) of the racemate and was purified by precipitation of the hydrochloride from aqueous solution at pH >6, dried and recrystallised from propan-2-ol. The R-hydrochloride [5967-73-7], when recrystallised from propan-2-ol, has m 245-246o, [] D 20 -169o (c 2, EtOH). The S-(+)-enantiomer [5653-8-5] also recrystallises from propan-2-ol and has recorded m of 100-101o, [] D 25 + 26o (c 1.2, H2O). The S-hydrochloride [15284-15-8], when crystallised from propan-2-ol, has m 243-244o, [] D 20 +169o (c 2, EtOH). [Larsen et al. J Am Chem Soc 70 4194 1948, Brode & Hill J Org Chem 13 191 1948, Schultz et al. J Am Chem Soc 69 2454 1947, Easton et al. J Am Chem Soc 69 2941 1947, Winter & Flataker J Pharmacol Exp Ther 98 305 1950, Beilstein 14 III 278, 1 4 III/IV 300.]

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