Sieber Linker
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Sieber Linker 속성
- 녹는점
- 243 °C
- 끓는 점
- 403.9±24.0 °C(Predicted)
- 밀도
- 1.395±0.06 g/cm3(Predicted)
- 저장 조건
- Store at 0°C
- 용해도
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- 산도 계수 (pKa)
- 7.52±0.20(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- White to Orange to Green
- InChI
- InChI=1S/C13H8O3/c14-8-5-6-10-12(7-8)16-11-4-2-1-3-9(11)13(10)15/h1-7,14H
- InChIKey
- XCJHDJAODLKGLG-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2)OC2=C1C=CC(O)=C2
- CAS 데이터베이스
- 3722-51-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
Sieber Linker C화학적 특성, 용도, 생산
화학적 성질
White to off-white or grey powder용도
Sieber linker (3-Hydroxyxanthen-9-one) is a natural product of the trifluoroacetic acid group found in Hypericum sampsonii and Rhachidosorus mesosorus. It has antiplatelet and anti-inflammatory properties. It also inhibits the expression of tumour necrosis factor-α (TNF-α) in mice. The synthesis of TNF-α is inhibited by Sieber linker, which may be due to its ability to inhibit the enzyme phosphodiesterase 4 (PDE4). Sieber linker also inhibits the binding of PDL1 to dinucleotide phosphate (DNP) and has an inhibitory effect on cancer cells. This molecule can be used for the treatment of infectious diseases, such as malaria and tuberculosis, since it inhibits protein synthesis in bacteria.Synthesis Reference(s)
Tetrahedron, 43, p. 3075, 1987 DOI: 10.1016/S0040-4020(01)86849-6Purification Methods
Purify the xanthone by chromatography on SiO2 gel with pet ether/*benzene as eluent. Recrystallise it from *benzene or EtOH. The acetate has m 157-158o. [Itoh et al. J Am Chem Soc 107 4819 1985, Davies et al. J Org Chem 23 307 1958]. [Beilstein 18 H 46, 18 I 315, 18 II 29, 21 III/IV 601.]Sieber Linker 준비 용품 및 원자재
원자재
피리딘 하이드로클로라이드
아니소일클로라이드
살리실산
o-Anisic acid
인산
디메톡시벤젠
염화 아연
포스포러스옥시클로라이드
레조시놀
염산
오산화 인
HARMOL
2,3,4,5,6,7,8,9-Octahydro-1H-trindene
STILBENE
자료없음
준비 용품
Sieber Linker 공급 업체
글로벌( 216)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Suzhou Eebetter Biotechnology Co., Ltd. | +8618914030027 |
happybaby7070@gmail.com | China | 7 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-13474506593 +86-13474506593 |
sarah@tnjone.com | China | 874 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Richest Group Ltd | 18017061086 |
oled@richest-group.com | CHINA | 5601 | 58 |