(S)-Timolol maleate
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(S)-Timolol maleate 속성
- 녹는점
- 202-203 °C(lit.)
- 알파
- 24405 -12.0° (c = 5 in 1N HCl); D25 -4.2°
- 저장 조건
- 2-8°C
- 용해도
- H2O: 용해성
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- optical activity
- [α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)
- Merck
- 14,9444
- InChIKey
- WLRMANUAADYWEA-NWASOUNVSA-N
- CAS 데이터베이스
- 26921-17-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-63-36/37/38 | ||
| 안전지침서 | 36-37/39-26 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | UA8475000 | ||
| HS 번호 | 29349990 | ||
| 기존화학 물질 | KE-11365 |
(S)-Timolol maleate C화학적 특성, 용도, 생산
개요
Timolol is a non-selective β-adrenergic receptor antagonist with log Kd values of -8.27, -9.86, and -6.8 for binding to human β1-, β2-, and β3-adrenoceptors, respectively. It has been reported that only the (S) enantiomer contributes to the β-blocking effects of racemic timolol, but the weakly active (R) isomer maintains a beneficial effect on intraocular pressure without the undesirable side-effect of bronchial constriction caused by non-selective action of (S)-timolol on β1 and β2 receptors. Timolol has been use alone and in fixed combinations with either prostaglandin analogs or carbonic anhydrase inhibitors to reduce intraocular pressure in research models of ocular hypertension and glaucoma.화학적 성질
White Solid용도
betaadrenergic blocker정의
ChEBI: The maleic acid salt of the active (S)-enantiomer of timolol, comprising equimolar amounts of (S)-timolol and maleic acid.생물학적 활성
β 1 -adrenergic blocker.(S)-Timolol maleate 준비 용품 및 원자재
원자재
준비 용품
(S)-Timolol maleate 공급 업체
글로벌( 307)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
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| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
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| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
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| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 |
info@pharmachemm.com | China | 241 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
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CHINA | 968 | 58 |