BAFILOMYCIN A1
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BAFILOMYCIN A1 속성
- 녹는점
- >106°C (dec.)
- 끓는 점
- 582.86°C (rough estimate)
- 밀도
- 1.0594 (rough estimate)
- 굴절률
- 1.5000 (estimate)
- RTECS 번호
- RN9781000
- 인화점
- 87℃
- 저장 조건
- -20°C
- 용해도
- DMSO에 용해됩니다(가온 시 최대 5mg/ml).
- 산도 계수 (pKa)
- 12.66±0.70(Predicted)
- 물리적 상태
- 분말 또는 고체
- 색상
- 흰색에서 황백색까지
- 수용성
- 메탄올, 에탄올, 아세톤 및 클로로포름에 용해됩니다. 물에 불용성.
- BRN
- 4730700
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
유엔번호(UN No.) | 3172 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 10 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29419090 |
BAFILOMYCIN A1 C화학적 특성, 용도, 생산
개요
Bafilomycin A1 is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases; Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases. Bafilomycin A1 (100 nM) inhibits autophagosome maturation and protein degradation in H-4-II-E cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) but not chloroquine-induced inhibition of macroautophagy. Bafilomycin A1 (100 nM) reduces viral yield in the culture supernatant of Vero E6 and Huh7 cells, as well as HEK293T cells expressing human angiotensin-converting enzyme 2 (ACE2), infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It also reduces lung RNA copy numbers and viral pneumonia in ACE2 transgenic mice infected with SARS-CoV-2 when administered at a dose of 0.1 mg/kg.화학적 성질
white to off-white powder용도
Bafilomycin A1 is a member of a potent family of macrocyclic lactones with broad spectrum biological activity, including activity against bacteria, yeast, fungi, nematodes, insects and tumour cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.정의
ChEBI: The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.일반 설명
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).생물학적 활성
Highly potent, selective inhibitor of vacuolar H + -ATPases (IC 50 = 500 pM as measured in chromaffin granule membranes). Selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca 2+ -ATPases, Na + /K + -ATPases and plasma membrane H + -ATPases.BAFILOMYCIN A1 준비 용품 및 원자재
원자재
준비 용품
BAFILOMYCIN A1 공급 업체
글로벌( 207)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shaanxi Dideu Medichem Co. Ltd | 18192627656 |
1012@dideu.com | China | 3269 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29067 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 |
sales@nextpeptide.com | China | 19915 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
BAFILOMYCIN A1 관련 검색:
진저롤
Bufalin
Thapsigargin
OLIGOMYCIN A
citreoviridin
BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO- MYCES SPECIES,bafilomycin b1from streptomyces sp.,BAFILOMYCIN B1
bafilomycin D
BAFILOMYCIN C1
BAFILOMYCIN A1
BAFILOMYCIN B2
BAFILOMYCIN B2 FROM STREPTOMYCES GRISEUS
BAFILOMYCIN B1 MONOHYDRATE
Bafilomycin D2'
Bafilomycin E
Bafilomycin D1
Bafilomycin C2
Bafilomycin A2
BAFILOMYCIN A1 (DRY ICE)