Amrinone

Amrinone 구조식 이미지
카스 번호:
60719-84-8
상품명:
Amrinone
동의어(영문):
inocor;AMRINONE;win40680;Cartonic;Vesistol;Wincoram;Imrinone;awd08-250;Amirinone;INAMRINONE
CBNumber:
CB3774164
분자식:
C10H9N3O
포뮬러 무게:
187.2
MOL 파일:
60719-84-8.mol
MSDS 파일:
SDS

Amrinone 속성

녹는점
294-297°C (dec.)
끓는 점
321.94°C (rough estimate)
밀도
1.2025 (rough estimate)
굴절률
1.4830 (estimate)
저장 조건
Keep in dark place,Sealed in dry,2-8°C
용해도
DMF: 0.3 mg/ml; DMSO: 0.5 mg/ml
물리적 상태
크리스탈
산도 계수 (pKa)
12.05±0.10(Predicted)
색상
DMF에서 결정화하여 얻은 결정
수용성
물이나 클로로포름에 용해되지 않습니다. 아세트산이나 DMF에 약간 용해됩니다. DMSO에 용해됨
CAS 데이터베이스
60719-84-8(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,Xn
위험 카페고리 넘버 25-36/37/38-20/21/22
안전지침서 28-45-36-26
유엔번호(UN No.) UN 2811 6.1/PG 3
WGK 독일 3
RTECS 번호 DW2500000
위험 등급 6.1(b)
포장분류 III
HS 번호 29333999
독성 LD50 orl-rat: 102 mg/kg NDADD8 1,259,83
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
NFPA 704
0
4 0

Amrinone C화학적 특성, 용도, 생산

개요

Amrinone is a positive inotropic agent useful in the management of severe congestive heart failure. It is effective even in unresponsive, fully digitalized patients.

화학적 성질

Crystalline Solid

용도

Amrinone is used for short-term treatment of cardiac insufficiency that does not respond to treatment of other drugs.

일반 설명

During normal heart function, cAMP performsimportant roles in regulating intracellular calcium levels.That is, certain calcium channels and storage sites forcalcium must be activated by cAMP-dependant protein kinases.Because cAMP plays an indirect role in the contractilityprocess, agents that inhibit its degradation will providemore calcium for cardiac contraction. One phosphodiesteraseenzyme that is involved in the hydrolysis of myocardiumcAMP is F-III. Amrinone, 5-amino (3,4 -dipyridin)-6 1 (H)-one (Inocor), possesses positive isotropic effects as aresult of its ability to inhibit this phosphodiesterase. In 1999,the USP Nomenclature Committee and the United StatesAdopted Names (USAN) Council approved changing thenonproprietary name and the current official monograph titleof amrinone to inamrinone. This change in nomenclature wasa result of amrinone being confused with amiodarone becauseof the similarity of the names. This was reported to cause confusionbetween the products that led to medication errors,some of which resulted in serious injury or death.

Safety Profile

Poison by ingestion andintravenous routes. Human systemic effects by ingestion:cardiac arrhythmias, liver function, thrombocytopenia. Anexperimental teratogen. Other experimental reproductiveeffects. When heated to decomposition it emits toxicfumes o

Amrinone 준비 용품 및 원자재

원자재

준비 용품


Amrinone 공급 업체

글로벌( 232)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 906 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17368 58

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