YM 298198 HYDROCHLORIDE;Thiazolo[3,2-a]benzimidazole-2-carboxamide,6-amino-N-cyclohexyl-N,3-dimethyl-;6-amino-N-cyclohexyl-N,3-dimethylbenzo[4,5]imidazo[2,1-b]thiazole-2-carboxamide;6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE
6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE C화학적 특성, 용도, 생산
생물학적 활성
Non-competitive antagonist with high affinity and selectivity for mGlu 1 receptors (K i = 19 nM); inactive at other mGlu receptor subtypes (mGlu 2-7 ), ionotropic receptors and glutamate transporters (IC 50 > 10 μ M). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC 50 values are 16 nM and 6.3 μ M respectively), and is orally active in vivo , demonstrating an antinociceptive effect in hyperalgesic mice.
6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE 준비 용품 및 원자재
