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레날리도마이드

레날리도마이드
레날리도마이드 구조식 이미지
카스 번호:
191732-72-6
한글명:
레날리도마이드
동의어(한글):
레날리도마이드
상품명:
Lenalidomide
동의어(영문):
CC-5013;Revlimi;Revlimid;lenalidomide;To the amine;LenalidoMide-d5;Lenalidomide ,98%;LenalidoMide (CC-5013);SGT67 lila@tuskwei.com;LenalidoMide (RevliMid)
CBNumber:
CB3855432
분자식:
C13H13N3O3
포뮬러 무게:
259.26062
MOL 파일:
191732-72-6.mol

레날리도마이드 속성

녹는점
269-271°C
끓는 점
614.0±55.0 °C(Predicted)
밀도
1.460±0.06 g/cm3(Predicted)
저장 조건
-20°C Freezer
산도 계수 (pKa)
10.75±0.40(Predicted)
CAS 데이터베이스
191732-72-6(CAS DataBase Reference)

안전

위험 카페고리 넘버 20/21/22
안전지침서 36/37
위험 등급 IRRITANT
HS 번호 29339900

레날리도마이드 C화학적 특성, 용도, 생산

개요

Lenalidomide is a derivative of thalidomide differing in the presence of an amino moiety in the 4-position and removal of one of the carbonyls of the phthaloyl ring. This derivative evolved from a structural-based effort to eliminate the adverse effects (somnolence, neuropathy, and teratogenicity) of thalidomide while maintaining or enhancing the appealing attributes. While the mechanism of action remains to be fully identified, lenalidomide inhibits TNF-a production in stimulated monocytes. In addition to inhibiting TNF-a secretion, the production of other pro-inflammatory cytokines is blocked. Complimentary to inhibition of pro-inflammatory cytokines, lenalidomide also increases the secretion of antiinflammatory cytokines, such as IL-10. Furthermore, lenalidomide inhibits secretion of angiogenic cytokines, VEGF and bFGF. Due to its immunomodulatory and antiangiogenic properties, lenalidomide has the potential for a wide spectrum of therapeutic applications. While other indications are under evaluation, lenalidomide has initially been launched for the treatment of myelodysplastic syndromes (MDS), a set of hematologic disorders that affect the bone marrow and result in a deficiency of mature blood cells. There are various types of MDS, and lenalidomide is approved for the type associated with a truncation of chromosome 5 known as deletion 5q MDS. In combination with dexamethasone, it has also been designated for the second-line treatment of multiple myeloma, a B cell malignancy characterized by excess monotypic plasma cells in the bone marrow. .

화학적 성질

Yellow Solid

Originator

Celgene (US)

용도

Immunomodulatory drug; analog of Thalidomide.

용도

Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.

용도

Lovastatin content <1% 98%

용도

A Thalidomide analog known to have immunomodulatory properties

정의

ChEBI: A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha.

상표명

Revlimid(Celgene).

레날리도마이드 준비 용품 및 원자재

원자재

준비 용품


레날리도마이드 공급 업체

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