니리다졸

니리다졸
니리다졸 구조식 이미지
카스 번호:
61-57-4
한글명:
니리다졸
동의어(한글):
니리다졸
상품명:
niridazole
동의어(영문):
BA32644;Ambilhar;niridazole;NSC-136947;Nitrothiamidazole;1-(5-NITRO-2-THIAZOLYL)-2-IMIDAZOLIDINONE;1-(5-nitrothiazol-2-yl)imidazolidin-2-one;2-Imidazolidinone, 1-(5-nitro-2-thiazolyl)-;1-(5-nitro-1,3-thiazol-2-yl)imidazolidin-2-one
CBNumber:
CB3896840
분자식:
C6H6N4O3S
포뮬러 무게:
214.204
MOL 파일:
61-57-4.mol
MSDS 파일:
SDS

니리다졸 속성

녹는점
260-262°
밀도
1.561 (estimate)
굴절률
1.6200 (estimate)
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
12.73±0.20(Predicted)
색상
DMF/MeOH의 황색 결정
수용성
0.13g/L(25℃)
IARC
2B (Vol. 13, Sup 7) 1987
EPA
Niridazole (61-57-4)

안전

유해 물질 데이터 61-57-4(Hazardous Substances Data)
독성 TDLo orl-rat: 8 g/kg/90W-I:NEO CALEDQ 4,305,78 orl-rat LD50:900 mg/kg FAZMAE 17,108,73

니리다졸 C화학적 특성, 용도, 생산

용도

Antischistosomal.

Pharmacology

Niridazole exhibits schistosomicide and amebicidal action. The mechanism of action is not known. It seems likely that it is concentrated in the parasite organism, which causes inhibition of phosphorylase activation, which is expressed in the depletion of glycogen reserves.
It also may inhibit spermatogenesis of parasites by affecting the production of eggs. It is used for diseases caused by Dracunculus meddinesis, as well as Shistosoma haematobium and Shistosoma mansoni. It belongs to a group of tertiary drugs and is used only in the absence of the drug of choice. Synonyms of this drug are ambilhar and others.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Used as an amoebicide and schistosomicidal agent.

니리다졸 준비 용품 및 원자재

원자재

준비 용품


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