Levothyroxine sodium
|
|
Levothyroxine sodium 속성
- 녹는점
- 207-210 (dec.)(lit.)
- 알파
- D20 -4.4° (c = 3 in 70% ethanol)
- 밀도
- d420 2.381
- 저장 조건
- Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- 세포 배양 배지: 0.1mg/mL
- 물리적 상태
- 가루
- BCS Class
- 1,3
- 안정성
- 흡습성
- InChIKey
- JMHCCAYJTTWMCX-QWPJCUCISA-M
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 안전지침서 | 22-24/25 | ||
|---|---|---|---|
| 유엔번호(UN No.) | 2811 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | YP2833760 | ||
| F 고인화성물질 | 3-8-10 | ||
| 위험 등급 | 6.1(a) | ||
| 포장분류 | II | ||
| HS 번호 | 2937909000 |
| 그림문자(GHS): |
 
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 신호 어: | Danger | |||||||||||||||||||||
| 유해·위험 문구: |
|
|||||||||||||||||||||
| 예방조치문구: |
|
Levothyroxine sodium C화학적 특성, 용도, 생산
화학적 성질
Levothyroxine sodium is White Solid용도
One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.Indications
Levothyroxine sodium (Levothroid, Synthroid, Levoxine) is the sodium salt of the naturally occurring levorotatory isomer of T4. It is the preparation of choice for maintenance of plasma T4 and T3 concentrations for thyroid hormone replacement therapy in hypothyroid patients. It is absorbed intact from the gastrointestinal tract, and its long half-life allows for convenient oncedaily administration. Since much of the T4 is deiodinated to T3, it is usually unnecessary to use more expensive preparations containing both T4 and T3.The aim is to establish euthyroidism with measured serum concentrations of T4, T3, and TSH within the normal range.The TSH-suppressive effects of exogenous T4 also prove useful in removing the stimulatory effects of TSH on the thyroid gland in the management of simple nonendemic goiter, chronic thyroiditis, and TSHdependent thyroid carcinoma.
정의
ChEBI: The sodium salt of L-thyoxine. It is used as replacement therapy in the treatment of hypothyroidism.일반 설명
Levothyroxine sodium,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-2-tyrosinemonosodium salt, hydrate (Synthroid, Letter, Levoxine,Levoid), is the sodium salt of the levo isomer of thyroxine,which is an active physiological principle obtained from thethyroid gland of domesticated animals used for food by humans.It is also prepared synthetically. The salt is a light yellow,tasteless, odorless powder. It is hygroscopic but stablein dry air at room temperature. It is soluble in alkali hydroxides,1:275 in alcohol, and 1:500 in water, to give a pH ofabout 8.9.Clinical Use
Liothyronine sodium occurs in vivo together withlevothyroxine sodium; it has the same qualitative activitiesas thyroxine but is more active. It is absorbed readily fromthe gastrointestinal tract, is cleared rapidly from the bloodstream,and is bound more loosely to plasma proteins than isthyroxine, probably because of the less acidic phenolic hydroxylgroup.Its uses are the same as those of levothyroxine sodium,including treatment of metabolic insufficiency, male infertility,and certain gynecological disorders.Levothyroxine sodium 준비 용품 및 원자재
원자재
티록신
아세트산(빙초산)
Sodium levothyroxine
수산화나트륨
염산
망간 설페이트 모노하이드레이트
IodoniuM,bis(4-Methoxyphenyl)-,iodide
bis(p-methoxyphenyl)iodonium bromide
N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester
Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate
L-Tyrosine,3,5-diiodo-o-(4-Methoxyphenyl)
N-Acetyl-3,5-diiodo-L-tyrosine
3,5-Diiodo-L-tyrosine dihydrate
준비 용품
Levothyroxine sodium 공급 업체
글로벌( 267)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 |
erin@hbldbiotech.com | China | 878 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 |
info@longyupharma.com | China | 2531 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| Hebei shuoxi biotechnology co. LTD | +8613081092107 |
CHINA | 968 | 58 | |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |