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프레드니솔원

프레드니솔원
프레드니솔원 구조식 이미지
카스 번호:
50-24-8
한글명:
프레드니솔원
동의어(한글):
프레드니솔론;프레드니솔원;코르티코스테론
상품명:
Prednisolone
동의어(영문):
deltaf;solone;steran;prednis;ulacort;dicortol;eazolind;hydeltra;predonin;Steaglate
CBNumber:
CB4109000
분자식:
C21H28O5
포뮬러 무게:
360.44
MOL 파일:
50-24-8.mol

프레드니솔원 속성

녹는점
240 °C (dec.)(lit.)
알파
D25 +102° (dioxane)
끓는 점
412.46°C (rough estimate)
밀도
1.0963 (rough estimate)
굴절률
100 ° (C=1, Dioxane)
인화점
2℃
저장 조건
-20°C Freezer
용해도
Very slightly soluble in water, soluble in ethanol (96 per cent) and in methanol, sparingly soluble in acetone, slightly soluble in methylene chloride. It shows polymorphism (5.9).
물리적 상태
powder
수용성
2.225g/L(25 ºC)
Merck
14,7721
BRN
1354103
InChIKey
OIGNJSKKLXVSLS-VWUMJDOOSA-N
CAS 데이터베이스
50-24-8(CAS DataBase Reference)
EPA
Prednisolone (50-24-8)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기
위험 카페고리 넘버
안전지침서
유해 물질 데이터 50-24-8(Hazardous Substances Data)
독성 LD50 oral in mouse: 1680mg/kg
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H360 태아 또는 생식능력에 손상을 일으킬 수 있음 생식독성 물질 구분 1A, 1B 위험
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P370+P378 화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.
P403+P235 환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.

프레드니솔원 MSDS


1,4-Pregnadiene-11b,17a,21-triol-3,20-dione

프레드니솔원 C화학적 특성, 용도, 생산

화학적 성질

Crystalline Solid

용도

Synthetic corticosteroid; metabolically interconvertible with prednisone

용도

glucocorticoid

용도

substance P antagonists (SPA). It mediates its effect by acting on neurokinin 1 receptor

정의

ChEBI: A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

상표명

Cortalone(Halsey); Delta-Cortef (Pharmacia & Upjohn); Fernisolone(Ferndale); Meti-Derm (Schering); Prelone (Muro); Prelone(Teva); Sterane (Pfizer).

일반 설명

Prednisolone,Δ1-hydrocortisone,11β,17,21-trihydroxypregna-1,4-diene-3,20-dione, hasless salt-retention activity than hydrocortisone, but some patients have more frequently experiencedcomplications such as gastric irritation and peptic ulcers.Because of low MC activity, it cannot be used alone for adrenalinsufficiency. Prednisolone is available in varioussalts and esters to maximize its therapeutic utility:
Prednisolone acetate, USP (21-acetate)
Prednisolone sodium phosphate, USP (21-sodiumphosphate)
Prednisolone sodium succinate, USP (21-sodiumsuccinate)
Prednisolone tebutate, USP (21-tebutate).

위험도

Causes sodium retention; may have side effects similar to cortisone.

Safety Profile

A poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects by an unspecified route: developmental abnormalities of the central nervous system; effects on embryo or fetus: fetal death, extra embryonic structures. Human reproductive effects by an unspecified route: stdlbirth. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Veterinary Drugs and Treatments

Glucocorticoids have been used in an attempt to treat practically every malady that afflicts man or animal, but there are three broad uses and dosage ranges for use of these agents. 1) Replacement of glucocorticoid activity in patients with adrenal insufficiency, 2) as an antiinflammatory agent, and 3) as an immunosuppressive. Among some of the uses for glucocorticoids include treatment of: endocrine conditions (e.g., adrenal insufficiency), rheumatic diseases (e.g., rheumatoid arthritis), collagen diseases (e.g., systemic lupus), allergic states, respiratory diseases (e.g., asthma), dermatologic diseases (e.g., pemphigus, allergic dermatoses), hematologic disorders (e.g., thrombocytopenias, autoimmune hemolytic anemias), neoplasias, nervous system disorders (increased CSF pressure), GI diseases (e.g., ulcerative colitis exacerbations), and renal diseases (e.g., nephrotic syndrome). Some glucocorticoids are used topically in the eye and skin for various conditions or are injected intra-articularly or intra-lesionally. The above listing is certainly not complete.
In general, in using glucocorticoids, the following principles should be followed:
1. Glucocorticoids can mask disease! Try not to use them until you have a diagnosis.
2. Make a specific diagnosis!
3. Determine course from outset.
4. Determine endpoint before you starting treating.
5. Use the least potent form for the minimal time.
6. Know where glucocorticoids inappropriate. (Behrend 2007)

프레드니솔원 준비 용품 및 원자재

원자재

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