Dacliximab

Dacliximab C화학적 특성, 용도, 생산

용도

Dacliximab is monoclonal antibody (immunosuppressant.

상표명

Zenapax (Hoffmann- LaRoche).

Clinical Use

Molecularly, daclizumab (Zenapax, Chimeric) is an IgG1MAb that binds specifically to the α subunit of the IL-2 receptor(the complete, high-affinity activated IL-2 receptorconsists of interacting α, β, and γ subunits). IL-2 receptorsare expressed on the surfaces of activated lymphocytes,where they mediate lymphocyte clonal expansion and differentiation.Daclizumab is a chimeric protein (90% humanand 10% mouse) IgG1. The MAb targets only recently activatedT cells that have interacted with antigen and have developedfrom their naive form into their activated form. Itis at this time that the IL-2 receptors are expressed. Thehuman amino acid sequences of daclizumab derive fromconstant domains of human IgG, and the variable domainsare derived from the fused Eu myeloma antibody. Themurine sequences derive from CDRs of a mouse anti-IL2αantibody.
The indications for daclizumab are prophylaxis of acuteorgan rejection in patients receiving renal transplants, aspart of an immunosuppressant regimen including cyclosporineand corticosteroids. The mechanism of action isthe same as that of basiliximab.

Dacliximab 준비 용품 및 원자재

원자재

준비 용품

Dacliximab 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12338	58
Clearsynth Canada Inc.	+1.415.685.4395	enquiry@clearsynth.com	Canada	912	58
Shanghai Han-Xiang Chemical Co., Ltd.	15971444841	amber@biochempartner.com	China	3063	58
Wuhan Chemstan Biotechnology Co., Ltd.	15926423062	422450190@qq.com	China	10132	58
AntibodySystem	027-65279366 18162686757	biolab-reagents@atagenix.com	China	9790	58
Wuhan Jingkangen Biomedical Technology Co., Ltd	13720134139 13720134139	orders@jknbiochem.com	China	4953	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	+86-18521732826	market@aladdin-e.com	China	48617	58
Changsha Fuzhen Biotechnology Co.，LTD	0731-18670069958 18670069958	184792226@qq.com	China	3000	58

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