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narciclasine

narciclasine 구조식 이미지

카스 번호:: 29477-83-6

상품명:: narciclasine

동의어(영문):: rciclasin;NSC 266535;Narciclasin;BRN 1087400;Lycorcidinol;narciclasine;Lycoricidin-A;Narciclasine, 99.9%;(13β)-1,19-Didehydro-2α,3β,4β,7-tetrahydroxy-11,12-dinor-5,19-secocrinan-6-one;3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one

CBNumber:: CB41341322

분자식:: C14H13NO7

포뮬러 무게:: 307.26

MOL 파일:: 29477-83-6.mol

속성

안전

용도

공급 업체 98

narciclasine 속성

녹는점: 250-252℃

끓는 점: 447.77°C (rough estimate)

밀도: 1.85±0.1 g/cm3 (20 ºC 760 Torr)

굴절률: 1.5300 (estimate)

저장 조건: Store at -20°C

용해도: DMSO: ≥10mg/mL

산도 계수 (pKa): 7.72±0.70(Predicted)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 흰색에서 황백색까지

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn
위험 카페고리 넘버	46
안전지침서	36

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H301	삼키면 유독함	급성 독성 물질 - 경구	구분 3	위험		P264, P270, P301+P310, P321, P330,P405, P501

예방조치문구:

narciclasine C화학적 특성, 용도, 생산

개요

Narciclasine is a plant growth inhibitor that can be isolated from Narcissus bulbs. At 1 μM, it has been shown to induce apoptosis-mediated cytotoxicity in human cancer cells in vitro but not in normal fibroblasts. Narciclasine has been shown to regulate the Rho/Rho kinase/LIM kinase/cofilin signaling pathway by increasing GTPase RhoA activity, as well as inducing actin stress fiber formation in a RhoA-dependent manner.

용도

Narciclasine is reasonably abundant in some Narcissus spp. and has served as a very useful intermediate for synthetic conversion into (+)-pancratistatin and to conduct a series of structure–activity relationship studies . Bicolorine, another member of the narciclasine series, is an unusual, completely aromatized quaternary alkaloid with an N-methyl group.

정의

ChEBI: A natural product found in Narcissus pseudonarcissus.

참고 문헌

Ceriotti., Nature, 213,595 (1967)
Piozzi et al., Tetrahedron, 24, 1119 (1968)
Revised structure: Mondon, Krohn., Tetrahedron Lett., 2123 (1970)
Savona, Piozzi, Marino., Chern. Cornrnun., 1006 (1970)
Absolute configuration: Fuganti, Mazza.,J. Chern. Soc., Chern. Cornrnun., 239 (1972)
Crystal structure: Immirzi, Fuganti., J. Chern. Soc., Chern. Cornrnun., 240 (1972)
Stereochemistry: Mondon, Krohn., Tetrahedron Lett., 2085 (1972)

narciclasine 준비 용품 및 원자재

원자재

준비 용품

narciclasine 공급 업체

글로벌( 98)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Aktin Chemicals, Inc.	028-85159085	info@aktinchem.com	CHINA	1025	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

narciclasine 관련 검색:

2,4-디히드록시-N-(2-히드록시에틸)벤즈아미드 Daurinoline daurisoline Colchicine N-Methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine 1-PHENYL-1-CYCLOHEXENE narciclasine 1-(3,4-Methylenedioxyphenyl)-2-butanamine 4-Methoxysalicylamide 6-METHYL-BENZO[1,3]DIOXOLE-5-CARBALDEHYDE 8-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 6-HYDROXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE 7,8-DIHYDRO-[1,3]DIOXOLO[4,5-G]ISOQUINOLIN-5(6H)-ONE 7-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL 6,7-DIHYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 7-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE