눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P330
입을 씻어내시오.
P332+P313
피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313
눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
P362
오염된 의복을 벗고 세척 후에 재사용하기
P403+P233
용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2
0
Peramivir C화학적 특성, 용도, 생산
개요
Peramivir is a neuraminidase (NA) inhibitor that was approved in Japan
in 2010 for treatment of patients with influenza. It is the only NA inhibitor
available for IV use and is the first of two NA inhibitors approved in 2010, the
second being the inhaled drug laninamivir octanoate .
Peramivir is the only NA inhibitor approved for IV use,which gives it a unique place in
influenza treatment for seriously ill patients. Peramivir was discovered
using structure-based drug design and is synthesized in six steps from
Boc-protected methyl (1S,4R)-4-amino-cyclopent-2-enecarboxylate, which
is prepared from 2-azabicyclo[2.2.1]hept-5-en-3-one. Cycloaddition
of the cyclopentene olefin with a nitrile oxide provided an intermediate
fused cyclopentane-dihydroisoxazole. Hydrogenolysis and acetylation set
up a fully functionalized cyclopentane with all four stereocenters established.
Deprotection of the amine and acid groups was followed by installation
of the guanidine moiety to provide peramivir. Like zanamivir and
oseltamivir, peramivir is a potent inhibitor of influenza virus A and B NA
[strain A(H1N1) IC50= 0.34 nM; strain A(H3N2) IC50= 0.60 nM; strain B
IC50= 1.36 nM]. However, peramivir is less potent against oseltamivirresistant
viruses that have the H275Y NA mutation. These viruses remain
sensitive to zanamivir. Peramivir is active against influenza A and B viruses
and has a lowenzymatic off-rate, suggesting that it could inhibitNAactivity
for a prolonged period and allow lower frequency of dosing. Peramivir has
proven efficacious in preclinical animal models of influenza infection.
화학적 성질
White to Off-White Solid
용도
Peramivir is a new antiviral agent for influenza treatment; it can be used as neuraminidase inhibitor for treating human and avian influenza
정의
Peramivir is a member of the class of guanidines that is used (as its trihydrate) for the treatment of acute uncomplicated influenza in patients 18 years and older who have been symptomatic for no more than two days.
