2-클로로-4-페닐퀴나졸린

2-클로로-4-페닐퀴나졸린
2-클로로-4-페닐퀴나졸린 구조식 이미지
카스 번호:
29874-83-7
한글명:
2-클로로-4-페닐퀴나졸린
동의어(한글):
2-클로로-4-페닐퀴나졸린
상품명:
2-CHLORO-4-PHENYLQUINAZOLINE
동의어(영문):
quinazoL;oro-4-phenyL;2-CHLORO-4-PHENYLQUIZOLINE;2-CHLORO-4-PHENYLQUINAZOLIN;2-Chloro-4-phenylq inazollne;2-CHLORO-4-PHENYLQUINAZOLINE;Quinazoline,2-chloro-4-phenyl-;2-CHLORO-4-PHENYLQUINAZOLINE ISO 9001:2015 REACH
CBNumber:
CB41490329
분자식:
C14H9ClN2
포뮬러 무게:
240.69
MOL 파일:
29874-83-7.mol

2-클로로-4-페닐퀴나졸린 속성

녹는점
113.0 to 117.0 °C
끓는 점
347.4±30.0 °C(Predicted)
밀도
1.285±0.06 g/cm3(Predicted)
저장 조건
under inert gas (nitrogen or Argon) at 2-8°C
물리적 상태
powder to crystal
산도 계수 (pKa)
0.24±0.30(Predicted)
색상
White to Orange to Green
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
HS 번호 2933998090
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
예방조치문구:
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

2-클로로-4-페닐퀴나졸린 C화학적 특성, 용도, 생산

용도

2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.

Synthesis

Synthesis_29874-83-7
A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).

2-클로로-4-페닐퀴나졸린 준비 용품 및 원자재

원자재

준비 용품


2-클로로-4-페닐퀴나졸린 공급 업체

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