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SULFAPHENAZOLE

SULFAPHENAZOLE 구조식 이미지

카스 번호:: 526-08-9

상품명:: SULFAPHENAZOLE

동의어(영문):: SP;TFF2;Sulfabid;Sulfaphenazol;Sulphaphenazole;Sulfaphenylpyrazole;SML1;Orisul;Inamil;Isarol

CBNumber:: CB4160540

분자식:: C15H14N4O2S

포뮬러 무게:: 314.36

MOL 파일:: 526-08-9.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 167

SULFAPHENAZOLE 속성

녹는점: 179-183 °C

끓는 점: 541.9±56.0 °C(Predicted)

밀도: 1.39

굴절률: 1.6440 (estimate)

저장 조건: 2-8°C

용해도: 클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): pKa 5.71(H2O t = 25 I = 0.05) (Uncertain)

색상: 흰색에서 밝은 노란색

안전

안전지침서	24/25
WGK 독일	2
RTECS 번호	DA9520000
HS 번호	29339900
독성	LD50 orally in mice: 5800 mg/kg (Seki)

SULFAPHENAZOLE C화학적 특성, 용도, 생산

개요

CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme’s activity can lead to adverse drug reactions. Sulfaphenazole is an inhibitor of CYP2C9 (K_i = 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (K_is = 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

화학적 성질

White to off-white powder

용도

Sulfaphenazole is used as an inhibitor for mammalian CYP2C9, an enzyme of the cytochrome P450 family allowing for pharmacological application. Sulfaphenazole can help protect against ischemia-reperfus ion, and resulting tissue damage by inhibition of CYP2C9.

정의

ChEBI: A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.

Purification Methods

Crystallise it from EtOH or aqueous EtOH. [Schmidt & Druey Helv Chim Acta 41 309 1958, Beilstein 25 III/IV 2029.]

SULFAPHENAZOLE 준비 용품 및 원자재

원자재

히드로아황산 나트륨 에틸알코올 오소포름산에틸 5-AMINO-1-PHENYLPYRAZOLE 클로로술폰산 초산에틸 염산 수산화나트륨 염화 티오닐 4-NITROBENZENESULFONIC ACID 페닐히드라진 석유 에테르 PHENYLURETHANE 에틸 사이아노아세테이트

준비 용품

SULFAPHENAZOLE 공급 업체

글로벌( 167)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81148696 +8615536356810	1047@dideu.com	China	3408	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58

SULFAPHENAZOLE 관련 검색:

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