카빈옥사민 말레인 산
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카빈옥사민 말레인 산 속성
- 녹는점
- 116-1180C
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 수용성
- Completely soluble in water
- 용해도
- Chloroform: Slightly Soluble; Methanol: Slightly Soluble
- 색상
- 흰색에서 거의 흰색
- Merck
- 14,1799
- InChIKey
- GVNWHCVWDRNXAZ-BTJKTKAUSA-N
- CAS 데이터베이스
- 3505-38-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25-36/37/38 | ||
| 안전지침서 | 26-36/37/39-45 | ||
| 유엔번호(UN No.) | 3249 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | US6350000 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 2933399090 | ||
| 독성 | LD50 in mice (mg/kg): 166 i.p. (Cahen) | ||
| 기존화학 물질 | KE-05863 |
카빈옥사민 말레인 산 C화학적 특성, 용도, 생산
개요
Carbinoxamine is a competitive histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine. It also competes with [3H]diltiazem, an L-type calcium channel blocker, for binding to the benzothiazepine site on rat cardiomyocytes (Ki = 1.08 nM). Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria by 76% (EC50 = 250 nM) and negative chronotropic activity in guinea pig spontaneously beating isolated right atria (EC50s = 250 and 480 nM, respectively) by 48% compared with control. Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis.화학적 성질
Off-White Solid용도
Analgesic and anti-inflammatory compound정의
ChEBI: The maleic acid salt of carbinoxamine. An ethanolamine-type antihistamine, used for treating hay fever, as well as mild cases of Parkinson's disease.일반 설명
Carbinoxamine is availableas a bitter bimaleate salt, (d, l)-2-[p-chloro- -[2-(dimethylamino)ethoxy]benzyl]pyridine bimaleate (Clistin), which isa white crystalline powder that is very soluble in water andfreely soluble in alcohol and in chloroform. The pH of a 1%solution is between 4.6 and 5.1.Carbinoxamine is a potent antihistaminic and is availableas the racemic mixture. It differs structurally from chlorpheniramineonly in having an oxygen atom separate theasymmetric carbon atom from the aminoethyl side chain. Themore active levo isomer of carbinoxamine has the (S) absoluteconfiguration and can be superimposed on the moreactive dextro isomer (S configuration) of chlorpheniramine.
카빈옥사민 말레인 산 준비 용품 및 원자재
원자재
준비 용품
카빈옥사민 말레인 산 공급 업체
글로벌( 199)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 |
1056@dideu.com | China | 3632 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 12468 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 |
mcbio_sales@163.com | China | 2255 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9358 | 58 |