트라이엠시놀론아세토나이드
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트라이엠시놀론아세토나이드 속성
- 녹는점
- 274-278°C (dec.)
- 알파
- D23 +109° (c = 0.75 in chloroform)
- 끓는 점
- 576.9±50.0 °C(Predicted)
- 밀도
- 1.1517 (estimate)
- 굴절률
- 1.5980 (estimate)
- 저장 조건
- Refrigerator
- 용해도
- 물에는 거의 녹지 않으며, 에탄올에는 거의 녹지 않습니다(96%).
- 산도 계수 (pKa)
- 12.87±0.10(Predicted)
- 색상
- 흰색에서 황백색까지
- 수용성
- DMSO 또는 에탄올에 용해됩니다. 물에 약간 용해됩니다.
- Merck
- 9596
- BCS Class
- 4
- 안정성
- 타기 쉬운. 강한 산화제와 호환되지 않습니다.
- InChIKey
- YNDXUCZADRHECN-JNQJZLCISA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T | ||
---|---|---|---|
위험 카페고리 넘버 | 61 | ||
안전지침서 | 53-45 | ||
WGK 독일 | 3 | ||
RTECS 번호 | TU3920000 | ||
TSCA | Yes | ||
HS 번호 | 29372290 | ||
독성 | LD50 oral in mouse: 5gm/kg |
트라이엠시놀론아세토나이드 C화학적 특성, 용도, 생산
개요
Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 μl of a 40 mg/ml suspension is administered subconjunctivally. Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.화학적 성질
White Solid정의
ChEBI: A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.Indications
Triamcinolone acetonide (Aristocort, Kenalog) is a synthetic fluorinated corticosteroid.일반 설명
The three main metabolitesof triamcinolone acetonide (Azmacort, Nasacort) are 6β-hydroxytriamcinolone acetonide, 21-carboxytriamcinoloneacetonide, and 6β-hydroxy-21-carboxytriamcinolone acetonide.All are much less active than the parent compound.The 6β-hydroxyl group and the 21-carboxy group are bothstructural features that greatly reduce GC action. The increasedwater solubility of these metabolites also facilitatesmore rapid excretion.Clinical Use
Triamcinolone acetonide used topically to treat various skin conditions, to relieve the discomfort of mouth sores, and by injection into joints to treat various joint conditions.Triamcinolone acetonide frequently is used by inhalation for the treatment of lung diseases (e.g., asthma).부작용
The side effects of using Triamcinolone acetonide include:Skin dryness, flaking, crusting, burning, or blistering; Skin irritation; Skin soreness, itching, swelling, scaling, or severe redness; Scaling or redness near mouth; Skin thinning or bruising, especially in skin folds (like between the finger) or on the face (when directed to use it there); New or worsening pimples or acne; Skin burning and itching with tiny red blisters; Skin softening; Itching, pain, or burning sensation in hairy areas, or pus at the root of the hair; Increased hair growth on the legs, arms, back, or forehead; Lightening of skin tone; Red or purple lines on the arms, face, legs, groin, or trunk.Safety Profile
Poison by subcutaneous and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and toxic fumes of F-.신진 대사
Triamcinolone acetonide frequently is used by inhalation for the treatment of lung diseases (e.g., asthma). After inhalation, triamcinolone acetonide can become systemically available when the inhaled formulation is swallowed and absorbed unchanged from the GI tract, causing undesirable systemic effects. Triamcinolone acetonide that is swallowed is metabolized to 6β-hydroxytriamcinolone acetonide, 21-carboxytriamcinolone acetonide, and 21-carboxy-6β-hydroxytriamcinolone acetonide, all of which are more hydrophilic than their parent drug. Only approximately 1% of the dose was recovered from the urine as triamcinolone acetonide. Triamcinolone is not a major metabolite of triamcinolone acetonide in humans, suggesting that acetonide is resistant to hydrolytic cleavage. Triamcinolone acetonide is approximately eight times more potent than prednisolone.트라이엠시놀론아세토나이드 준비 용품 및 원자재
원자재
아세톤
트라이엠시놀론
Pregn-4-ene-3,20-dione, 16,21-bis(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β,16α)- (9CI)
21-hydroxypregna-4,9(11),16-triene-3,20-dione 21-acetate
16alpha,17,21-trihydroxypregna-4,9(11)-diene-3,20-dione 21-acetate
Pregn-4-ene-3,20-dione, 9-bromo-21-(formyloxy)-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)- (9CI)
11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione
9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
준비 용품
트라이엠시놀론아세토나이드 공급 업체
글로벌( 606)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hangzhou Verychem Science And Technology Co.Ltd | +86-86-57188162785 13606544505 |
lucy@verychem.com | China | 1001 | 58 |
Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 |
sean.lv@synzest.com | China | 323 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11013 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 524 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-13474506593 +86-13474506593 |
sarah@tnjone.com | China | 794 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15371 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 |
bj1@bj-chem.com | China | 298 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
트라이엠시놀론아세토나이드 관련 검색:
1-히드록시에틸리덴-1,1-디포스포닌산 하이드록시에틸 셀룰로스 히드록실아파타이트
Triamcinolone hexacetonide
Hydroxy silicone oil
Triamcinolone acetonide 21-acetate
Ethyl maltol
Hydroxyethyl starch
Triamcinolone
fluocinolone16,17-acetonide
Fluocinonide
Fluocinolone Acetonide-21-carboxylic Acid
6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate
21-Acetyl-6β-fluorotriamcinolone Acetonide
9beta,11beta-epoxy-6alpha-fluoro-21-hydroxy-16alpha,17-(isopropylidene)dioxypregna-1,4-diene-3,20-dione
(6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-21-Methoxy-16,17-[(1-Methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
Fluocinolone Acetonide Impurity 2
Fluocoutolone Hexanoate