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트리부틸인산염

트리부틸인산염
트리부틸인산염 구조식 이미지
카스 번호:
126-73-8
한글명:
트리부틸인산염
동의어(한글):
인산트리부틸에스테르;인산,트리부틸에스테르;트리부톡시포스핀산화물;트리부틸인산;트리부틸포스페이트;트리부틸인산염;트리부틸포스페이트;트라이부틸포스페이트
상품명:
Tributyl phosphate
동의어(영문):
TBP;mcs2495;tributyl;Tributyle;ANTIFOAM T;celluphos4;Celluphos 4;Phos-Ad 100;disflamolltb;Kronitex TBP
CBNumber:
CB4187323
분자식:
C12H27O4P
포뮬러 무게:
266.31
MOL 파일:
126-73-8.mol

트리부틸인산염 속성

녹는점
-79 °C
끓는 점
289 °C
밀도
0.979 g/mL at 25 °C(lit.)
증기 밀도
9.2 (vs air)
증기압
27 mm Hg ( 178 °C)
굴절률
n20/D 1.424(lit.)
인화점
380 °F
저장 조건
Store below +30°C.
용해도
water: soluble1ml in 165ml water
물리적 상태
Liquid
색상
Clear
수용성
0.6 g/100 mL
Merck
14,9618
BRN
1710584
노출 한도
TLV-TWA 2.18 mg/m3 (0.2 ppm) (ACGIH), 5 mg/m3 (OSHA and NIOSH); IDLH 1300 mg/m3 (120 ppm) (NIOSH).
안정성
Stable. Combustible. Incompatible with strong oxidizing agents. May be water sensitive.
CAS 데이터베이스
126-73-8(CAS DataBase Reference)
NIST
Tri-n-butylphosphate(126-73-8)
EPA
Phosphoric acid tributyl ester(126-73-8)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,F
위험 카페고리 넘버 22-38-40-62-48/20-36/37/38-11-20/22
안전지침서 36/37-46-45-36/37/39-16-53
유엔번호(UN No.) UN 1208 3/PG 2
WGK 독일 2
RTECS 번호 TC7700000
자연 발화 온도 770 °F
TSCA Yes
HS 번호 29190010
유해 물질 데이터 126-73-8(Hazardous Substances Data)
독성 LD50 orally in rats: 3.0 g/kg (Smyth, Carpenter)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H351 암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
H412 장기적 영향에 의해 수생생물에 유해함 수생 환경유해성 물질 - 만성 구분 3 P273, P501
예방조치문구:
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P315 즉시 의사의 진료/치료를 받을 것
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

트리부틸인산염 MSDS


TBP

트리부틸인산염 C화학적 특성, 용도, 생산

개요

On decomposition, TBP releases COx, toxic fumes of phosphoric acid, phosphorus oxides, and/or phosphine. TBP is incompatible with strong oxidising agents and alkalis. The major uses of TBP in industry are as a component of aircraft hydraulic fluid and as a solvent for rare earth extraction and purification. Minor uses of TBP include use as a defoamer additive in cement casings for oil wells, an anti-air entrainment additive for coatings and floor finishes, as well as a carrier for fluorescent dyes. The major uses of TBP comprise over 80% of the volume produced.

화학적 성질

Stable, colorless liquid; odorless. Miscible with most solvents and diluents; soluble in water. Combustible.

물리적 성질

Clear, colorless to pale yellow, odorless, slightly flammable, oily liquid

용도

Tributyl phosphate is used as a plasticizer for cellulose esters, vinyl resins, and lacquers; and in making fireretardants, biocides, defoamers, and catalysts.

용도

Extractant for metal complexes.1

용도

Plasticizer for cellulose esters, lacquers, plastics, and vinyl resins.

정의

ChEBI: A trialkyl phosphate that is the tributyl ester of phosphoric acid.

생산 방법

Prepared by the reaction of phosphorus oxychloride with butyl alcohol.

공기와 물의 반응

Water insoluble. Reacts slowly with water under basic conditions.

반응 프로필

Tributyl phosphate is incompatible with strong oxidizing agents and strong bases. Attacks some forms of plastics and rubber .

건강위험

Toxic by ingestion and inhalation, irritant to skin, bladder, eye and upper respiratory tract. May cause stimulation of the central nervous system.

건강위험

Acute
Non-industrial:
There are no data on the toxicity of TBP to man. The TLV is established by the American Council of Governmental Industrial Hygienists on the basis of analogy with triphenyl phosphate with which it bears some similarities in its toxic properties (ACGIH 1986).
Industrial:
A personal communication to ACGIH notes that workers exposed to 15 mg/m3 of TBP have complained of nausea and headache (ACGIH 1986). There are no other documented reports of deleterious effects of TBP in industrial situations.
Chronic
Inhibition of human erythrocyte and plasma cholinesterase is reported to be weak, even in vitro (Hayes and Sabine 1952; Sandmeyer and Kirwin 1981).

건강위험

Tributyl phosphate is a neurotoxic compound and an irritant. The toxic effects are characteristic of organic phosphates. It inhibits cholinesterase activity and causes paralysis. Inaddition,itcancausedepressionofthecentralnervoussystem,aswellasirritationofthe skin,eyes,andrespiratorypassage.Inhalation toxicity data in the literature are inconsistent.
The oral toxicity in rats was low; the LD50 value was reported as 1189 mg/kg (NIOSH 1986).
The pure liquid instilled into rabbits’ eyes caused severe irritation but no permanent damage. The irritation effect on the skin is mild.
Tributyl phosphate exhibited teratogenic effects in rats. There is no report on its carcinogenicity..

화재위험

Special Hazards of Combustion Products: Toxic fumes of PO x

공업 용도

1. As an antifoaming agent.
2. As a plasticizer for cellulose esters, lacquers, plastics, and vinyl resins.
3. As a complexing agent in the extraction of heavy metals, especially for the extraction of metal ions from solutions of reactor products in nuclear fuel reprocessing.
4. As an aircraft hydraulic fluid.
5. As a heat exchange medium and dielectric.
6. As a pigment-grinding agent.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion, inhalation, and subcutaneous routes. Experimental reproductive effects. A skin, eye, and mucous membrane irritant. Combustible when exposed to heat or flame. To fight fire, use CO2, dry chemical, fog, mist. When heated to decomposition it emits toxic fumes of POx.

환경귀착

Biological. Indigenous microbes in Mississippi River water degraded tributyl phosphate to carbon dioxide. After 4 wk, 90.8% of the theoretical carbon dioxide had evolved (Saeger et al., 1979).
Chemical/Physical. Complete hydrolysis yields 1-butanol and phosphoric acid via the intermediates dibutyl phosphate and monobutyl phosphate (Thomas and Macaskie, 1996).

신진 대사

A system was developed utilizing isolated anterior forearm stratum corneum conjunctum of man to study skin penetrating capacity of a series of organic phosphates. TBP was tested in the system and was among the least penetrating of the compounds tested, only phosphoric acid and tri-o-cresyl phosphate penetrating less well. The value given was μmoles/cm2/min as the average maximum steady-state rate of penetration. In a comparative study with 3 living subjects, penetration was essentially the same as in the isolated skin preparation (Marzulli et al 1965).
Rats given a single oral dose of [14C]-labeled TBP at 14 mg/kg excreted 50, 10, and 6% of the administered dose in the urine, exhaled air, and feces, respectively, within 24 h. A single intraperitoneal dose at the same rate resulted in 70,7, and 4% of the administered dose in the urine, exhaled air, and feces within the first 24 h (Suzuki et al 1984).
Single oral administration of TBP to rats at 156 mg/kg led to its appearance in all the tissues in the first 30 min. The major amount was in the gastrointestinal tract where it was poorly absorbed and was rapidly eliminated. The total level of TBP in all other organs and tissues was 5.73%, but none was detected after 3 d (Khalturin and Andryushkeeva 1986).
A single i.p. dose of TBP at 250 mg/kg to rats resulted in 11 phosphoruscontaining metabolites in the urine within 24 h. The principal metabolic pathway resulted in stepwise debutylation, through hydroxylated intermediates, to give dibutyl hydrogen phosphate and butyl dihydrogen phosphate. Butyl bis(3-hydroxybutyl) phosphate and small amounts of monohydroxylated butyl derivatives also were isolated. Several metabolites, presumably resulting from omegaoxidation of the ?-butyl moieties to give butyric acid derivatives, also were detected, the result of a secondary pathway. In addition, butyl 2-hydroxybutyl hydrogen phosphate was isolated and characterized. The administration of a possible intermediate, dibutyl 3-oxobutyl phosphate, gave a metabolic profile similar to that of dibutyl 3-hydroxybutyl phosphate, the major metabolite, thus supporting the view that this compound was on the major metabolic pathway. Separate direct administration of various hydroxylated metabolites supported the metabolic pathways proposed (Suzuki et al 1984).
Rat liver microsomal preparations also metabolized TBP to mono- and dihydroxylated intermediates, giving dibutyl hydrogen phosphate as the terminal metabolite (Sasaki et al 1984). Microsomal preparations from goldfish liver and killifish also resulted in dibutyl 3-hydroxybutyl phosphate and dibutyl hydrogen phosphate (Sasaki et al 1985).

Purification Methods

The main contaminants in commercial samples are organic pyrophosphates, monoand dibutyl phosphates and butanol. It is purified by washing successively with 0.2M HNO3 (three times), 0.2M NaOH (three times) and water (three times), then fractionally distilled under vacuum. [Yoshida J Inorg Nucl Chem 24 1257 1962.] It has also been purified via its uranyl nitrate addition compound, obtained by saturating the crude phosphate with uranyl nitrate. This compound is crystallised three times from n-hexane by cooling to -40o, and then decomposed by washing with Na2CO3 and water. Hexane is removed by steam distillation; the water is then evaporated under reduced pressure, and the residue is distilled under reduced pressure. [Siddall & Dukes J Am Chem Soc 81 790 1959.] Alternatively, wash it with water, then with 1% NaOH or 5% Na2CO3 for several hours, then finally with water. Dry it under reduced pressure and fractionate it carefully under vacuum. It is a stable colourless oil, sparingly soluble in H2O (1mL dissolves in 165mL of H2O), but freely miscible in organic solvents. [Kuivila & Masterton J Am Chem Soc 74 4953 1952, Cox & Westheimer J Am Chem Soc 80 5441 1958, 31P NMR: Van Wazer J Am Chem Soc 78 5715 1956, Fertig et al. J Chem Soc 1488 1957, Beilstein 1 IV 1531.]

폐기물 처리

Tributyl phosphate is dissolved in a combustible solvent and is burned in a chemical incinerator equipped with an afterburner and scrubber.

트리부틸인산염 준비 용품 및 원자재

원자재

준비 용품


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