LEUROSINE

LEUROSINE 구조식 이미지
카스 번호:
23360-92-1
상품명:
LEUROSINE
동의어(영문):
amotin;LEUROSINE;nsc-528004;Vinleurosine;Vincristine EP Impurity F;Vincristine EP Impurity F (Leurosine);4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI;(3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine;Vincristine Impurity 6(Vincristine EP Impurity F);4′-deoxy-3′α,4′α-epoxyvincaleukoblastine(leurosine)
CBNumber:
CB4205283
분자식:
C46H56N4O9
포뮬러 무게:
808.97
MOL 파일:
23360-92-1.mol

LEUROSINE 속성

녹는점
202-205℃
밀도
1.39
산도 계수 (pKa)
11.36±0.60(Predicted)

안전

유엔번호(UN No.) 1544
위험 등급 6.1(a)
포장분류 II
유해 물질 데이터 23360-92-1(Hazardous Substances Data)
독성 dog,LDLo,intraperitoneal,12mg/kg (12mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987.

LEUROSINE C화학적 특성, 용도, 생산

개요

Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals that are best purified by recrystallization from acetonitrile. It crystallizes with 8 moles of H20 and loses solvent when heated at In-5°C. It is also dextro? rotatory with [α]26D + n° (CHCI3)’ A crystalline SUlphate is known which has m.p. 238-242°C (dec.) and [α]D - 8.3° (MeOH). The N(b)-oxide is identical with pleurosine (q.v.).

용도

Vinleurosine is an antitumor compound derived from Vinca Rosea.

참고 문헌

Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)

LEUROSINE 준비 용품 및 원자재

원자재

준비 용품


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