TUNICAMYCIN
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TUNICAMYCIN 속성
- 녹는점
- 234-235℃ (decomposition)
- 알파
- D20 +52° (c = 0.5 in pyridine)
- 인화점
- 87℃
- 저장 조건
- 2-8°C
- 용해도
- 메탄올, 에탄올, DMSO 또는 DMF에 용해됨
- 물리적 상태
- 흰색에서 회백색 고체
- 색상
- 하얀색
- 감도
- Moisture & Light Sensitive
- BRN
- 6888090
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
- InChIKey
- YJQCOFNZVFGCAF-WPTOCQRYSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T+,T | ||
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위험 카페고리 넘버 | 28 | ||
안전지침서 | 28-37/39-45 | ||
유엔번호(UN No.) | UN 3462 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | YO7980200 | ||
F 고인화성물질 | 8-10-18-21 | ||
위험 등급 | 6.1(a) | ||
포장분류 | II | ||
HS 번호 | 29419090 |
TUNICAMYCIN C화학적 특성, 용도, 생산
개요
Tunicamycin mixture is a mixture of tunicamycins with variable trans-2,3-unsaturated branched chain fatty acid (BFCA) chain lengths. Tunicamycins are anti-microbial agents that are active against Gram-positive bacteria, fungi, and viruses. They inhibit the N-acetylhexosamine (HexNAc) phosphotransferase family of enzymes in bacteria and prevent peptidoglycan biosynthesis. In eukaryotes, they inhibit N-acetylglucosamine (GlcNAc) phosphotransferase (GPT), preventing the first step in N-linked glycosylation and inducing the unfolded protein response and cell death. The cellular toxicity of tunicamycins is linked to the trans-2,3-unsaturated BCFA, and saturated BCFA-containing tunicamycin derivatives, such as TunR1 and TunR2 , have reduced toxicity. Tunicamycins impair glycosylation of the receptor tyrosine kinases EGFR, HER2, HER3, and IGF-1R, which prevents their translocation out of the endoplasmic reticulum and Golgi apparatus and reduces their protein levels and activity. Tunicamycin sensitizes EGFR inhibitor-resistant U251 glioma and Bx/PC-3 pancreatic adenocarcinoma cells to irradiation.화학적 성질
White solid용도
The tunicamycins are a family of lipophilic nucleosides with fatty acids conjugated to an aminoglycoside group. The complex comprises analogues, tunicamycins I to X. This composition is typical of other products less precisely described as tunicamycins A to D. The tunicamycins act by blocking the formation of N-glycoside linkages to proteins via inhibition of formation of dolichol monophosphate from N-acetylglucosamine-1-phosphate. Tunicamycin blocks the synthesis of all N-linked glycoproteins (N-glycans) and causes cell cycle arrest in G1 phase. Tunicamycins are broadly active against prokaryotes, eukaryotes and viruses.정의
ChEBI: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty aci linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.일반 설명
Tunicamycin was first isolated from Streptomyces lysosuperificus based on its antiviral activity. It contains N-acetylglucosamine and inhibits glycoprotein biosynthesis, including virus membrane glycoproteins.Purification Methods
The components of this nucleotide antibiotic from Streptomyces sp. are purified by recrystallising 3 times from hot glass-distilled MeOH, and the white crystals are dissolved in 25% aqueous MeOH and separated on a Partisil ODS-10_ column (9.4 x 25 cm) [Magnum-9 Whatman] using a 260nm detector. The column is eluted with MeOH/H2O mixture adjusted to 1:4 (v/v) then to 2:4 (v/v). The individual components are recovered and lyophilised. Ten components have been isolated, and all were active (to varying extents) depending on the lengths of the aliphatic side-chains. The mixture has UV max at 205 and 260nm (A 1cm 230 and 110). It is stable in H2O at neutral pH but unstable in acidic solution. It inhibits protein glycosylation. [Mahoney & Duskin J Biol Chem 254 6572 1979, Elnein Trends Biochem Sci 6 219 1981, Takatsuki J Antibiot 24 215 1971.] Uracil, uridine and uridine nucleotides. These are resolved by ion-exchange chromatography with AG1 (Cl form). [Lindsay et al. Anal Biochem 24 506 1968.]TUNICAMYCIN 준비 용품 및 원자재
원자재
준비 용품
TUNICAMYCIN 공급 업체
글로벌( 188)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 |
wendy@huidabiotech.com | CHINA | 87 | 58 |
HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 |
ada@ipurechemical.com | CHINA | 3465 | 58 |
TUNICAMYCIN 관련 검색:
1,10-디아미노데칸 1,2,7,8-옥탄테트롤
TUNICAMYCIN
8-DIMETHYLAMINO-1-OCTANOL
10-AMINO-1-DECANOL
ACETALDEHYDE DI-N-HEXYL ACETAL
1,5-BIS(METHYLAMINO)-3-OXAPENTANE, 98
3-Acryloylamino-1-propanol solution, 50% in water
DIPENTOXYETHANE
N-(2-Hydroxyethyl)acrylamide, HEAA
N-DECYL ACRYLAMIDE
TETRAHYDRO-2H-PYRAN-2-ETHANOL
TUNICAMYCIN C1),TUNICAMYCIN B COMPLEX,tunicamycin C1 homolog
TUNICAMYCIN A1 HOMOLOG,tunicamycin A1
TUNICAMYCIN UN3172 (III)
10 MG TUNICAMYCIN FROMSTEPTOMYCES CHARTREUSIS
reducing agent and tunicamycin-responsive protein
tunicamycin B3