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셀룰로스 구조식 이미지
카스 번호:
Microcrystalline cellulose
포뮬러 무게:
MOL 파일:

셀룰로스 속성

76-78 °C(Solv: acetone (67-64-1); chloroform (67-66-3))
1.5 g/cm3 (20℃)
n20/D 1.504
164 °C
저장 조건
room temp
Practically insoluble in water, in acetone, in anhydrous ethanol, in toluene, in dilute acids and in a 50 g/L solution of sodium hydroxide
물리적 상태
White or almost white
5-7.5 (100g/l, H2O, 20℃)(slurry)
Stable. Combustible. Incompatible with strong oxidizing agents.
Cellulose (9004-34-6)
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 37
안전지침서 24/25
WGK 독일 3
RTECS 번호 FJ5950200
F 고인화성물질 3
자연 발화 온도 232 °C
HS 번호 39129090
독성 LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
기존화학 물질 KE-05339
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P405 밀봉하여 저장하시오.
P403+P233 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
NFPA 704
1 0

셀룰로스 MSDS

Cellulose microcrystalline

셀룰로스 C화학적 특성, 용도, 생산


Microcrystalline Cellulose (MCC)는 많은 나라에서 인기있는 식품 첨가물 및 성분 중 하나입니다.
이 제품은 타블렛 접착제, 희석제, 붕괴 제; 캡슐 희석제 등 건강 식품 부형제, 액체 비료, 필러로 사용할 수 있습니다.
기타 용도 : 중요한 기능성 식품 섬유로 식품 산업에서 미세 결정 성 셀룰로오스는 이상적인 건강 식품 첨가물이며, 미정 질 셀룰로오스는 식품 제조시 텍스타이 라이저, 고결 방지제, 지방 대체제, 유화제, 증량제 및 벌킹 제로 사용할 수 있습니다. Microcrystalline Cellulose의 가장 보편적 인 사용법은 비타민 보충제 또는 정제에 첨가됩니다.
또한 바이러스 계산을위한 플라크 (plaque) 분석에 사용될 수 있습니다. 이번에, Microcrystalline Cellulose는 카르복시 메틸 셀룰로오스에 대한 대안입니다.

화학적 성질

Microcrystalline cellulose and carboxymethylcellulose sodium occurs as a white or off-white odorless and tasteless hygroscopic powder containing 5–22% sodium carboxymethylcellulose. It is a water-dispersible organic hydrocolloid.

화학적 성질

Microcrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. It is commercially available in different particle sizes and moisture grades that have different properties and applications.


The fiber in typical paper can be called “cellulosic”, meaning that cellulose is its most prominent component. Cellulose is present not only in wood, but also in various non-woody plants, such as straw, sugarcane (bagasse), reeds, and hemp.


High purity cellulose powders for partition chromatography.


ACCEL-101 is most widely used for direct compression tableting and wet granulation. ACCEL-102 has similar compression properties to ACCEL-101. However, it has larger particle size and therefore, may be of value in improving the flow if fine powders. ACCEL


cellulose is a thickener and an emulsifier. It is obtained from plants. cellulose (microcrystalline) is used as an emulsifier in cosmetic creams. It is the chief constituent of plant fiber.


Wood contains 50–70% cellulose; cotton and other textile fibers of plant origin contain 65–95%; rayon is prepared by dissolving natural cellulose and then precipitating it from solution, with some loss of crystallinity. Cellulose is made into cellophane film and is used to form fibers, resins, coatings and gums.


Cellulose is a carbohydrate polymer made up of glucose units. It consists of fibrous particles and is used as a fiber source and bulking agent in low-calorie formulations.


Microcrystalline Cellulose is a gum that is the nonfibrous form of cellulose, an alpha-cellulose. It is dispersible in water but not soluble, requiring considerable energy to disperse and hydrate. In this form it is used in dry applications such as tableting, capsules, and shredded cheese where it functions as a non-nutritive filler, binder, flow aid, and anticaking agent. By the addition of carboxymethylcellulose to the alpha-cellulose prior to drying, improved functional properties of hydration and dispersion are obtained. This product is designed for use in water dispersions, being insoluble in water but dispersing in water to form colloidal sols below 1% and white opaque gels above the 1% usage level. It is used as a heat shock stabilizer and bodying agent in frozen desserts, as an opacifier in low-fat dressings, as a foam stabilizer in whipped toppings, and as an emulsifier in dressings. Also termed cellulose gel.


A natural carbohydrate high polymer (polysaccha- ride) consisting of anhydroglucose units joined by an oxygen linkage to form long molecular chains that are essentially linear. It can be hydrolyzed to glucose. The degree of polymerization is from 1000 for wood pulp to 3500 for cotton fiber, giving a molecular weight from 160,000 to 560,000. Cellulose is a colorless solid, d approximately 1.50, insoluble in water and organic solvents. It will swell in sodium hydroxide solution and is soluble in Schweitzer’s reagent. It is the fundamental con- stituent of all vegetable tissues (wood, grass, cotton, etc.) and the most abundant organic material in the world. Cotton fibers are almost pure cellulose; wood contains approximately 50%. The physical structure of cellulose is unusual in that it is not a single crystal but consists of crystalline areas embedded in amorphous areas. Chemical reagents penetrate the latter more easily than the former. Cel- lulose is virtually odorless and tasteless and is com- bustible, with an ignition point of approximately 450F. In some forms, it is flammable. For example, railroad shipping regulations require a flammable label on such items as burnt fiber, burnt cotton, wet waste paper, and wet textiles. Fires have been known to occur in warehouses in which telephone books were stored. These were undoubtedly due to heat buildup in the paper caused by microbial activity and self-sustaining oxidation.

생산 방법

Microcrystalline cellulose and carboxymethylcellulose sodium is a spray- or bulk-dried blend of microcrystalline cellulose and sodium carboxymethylcellulose. It is prepared by the chemical depolymerization of highly purified wood pulp. The original crystalline areas of the pulp fibers are combined with sodium carboxymethylcellulose, which serves as a protective colloid and also facilitates dispersion of the product; it is then either spray- or bulk-dried.

생산 방법

Microcrystalline cellulose is manufactured by controlled hydrolysis with dilute mineral acid solutions of α-cellulose, obtained as a pulp from fibrous plant materials. Following hydrolysis, the hydrocellulose is purified by filtration and the aqueous slurry is spraydried to form dry, porous particles of a broad size distribution.

일반 설명

Odorless, white powdery fibers. Density 1.5 g cm-3. The biopolymer composing the cell wall of vegetable tissues. Prepared by treating cotton with an organic solvent to de-wax Cellulose microcrystalline and removing pectic acids by extration with a solution of sodium hydroxide. The principal fiber composing the cell wall of vegetable tissues (wood, cotton, flax, grass, etc.). Technical uses depend on the strength and flexibility of its fibers. Insoluble in water. Soluble with chemical degradation in sulfuric aicd, and in concentrated solutions of zinc chloride. Soluble in aqueous solutions of cupric ammonium hydroxide (Cu(NH3)4(OH)2).

반응 프로필

Cellulose microcrystalline is combustible. Incompatible with strong oxidizing agents including bromine pentafluoride, sodium nitrate, fluorine, perchlorates, perchloric acid, sodium chlorate, magnesium perchlorate, F2, zinc permanganate, sodium nitrite, sodium nitrate, sodium peroxide. Nitration with a mixture of nitric and sulfuric acids produces Cellulose microcrystalline nitrates (celluloid pyroxylin, soluble pyroxyline, guncotton) which are flammable or explosive.


Cellulose is inert and is classified as a nuisance dust.
It has little, if any, adverse effect on the lung, and there are no reports of organic disease or toxic effect. The health effects attributed to wood, cotton, flax, jute, and hemp are not attributable to their cellulose content but rather to the presence of other substances.
Cellulose fibers were found in the blood and urine of human volunteers fed dyed cellulose; there were no ill effects.

Pharmaceutical Applications

Microcrystalline cellulose and carboxymethylcellulose sodium is used to produce thixotropic gels suitable as suspending vehicles in pharmaceutical and cosmetic formulations. The sodium carboxymethylcellulose aids dispersion and serves as a protective colloid.
Concentrations of less than 1% solids produce fluid dispersions, while concentrations of more than 1.2% solids produce thixotropic gels. When properly dispersed, it imparts emulsion stability, opacity and suspension in a variety of products, and is used in nasal sprays, topical sprays and lotions, oral suspensions, emulsions, creams and gels.

공업 용도

Cellulose is the main constituent of the structureof plants (natural polymer) that, whenextracted, is employed for making paper,plastics, and in many combinations. Celluloseis made up of long-chain molecules inwhich the complex unit C6H10O5 is repeatedas many as 2000 times. It consists of glucose molecules with three hydroxyl groups foreach glucose unit.
One of the simplest forms of cellulose usedindustrially is regenerated cellulose, in whichthe chemical composition of the finished productis similar to that of the original cellulose. Itis made from wood or cotton pulp digested ina caustic solution. Cellophane is a regeneratedcellulose in thin sheets for wrapping and otherspecial uses include windings on wire andcable.

Safety Profile

A nuisance dust. When heated to decomposition it emits acrid smoke and irritating fumes.


Microcrystalline cellulose is widely used in oral pharmaceutical formulations and food products and is generally regarded as a relatively nontoxic and nonirritant material.
Microcrystalline cellulose is not absorbed systemically following oral administration and thus has little toxic potential. Consumption of large quantities of cellulose may have a laxative effect, although this is unlikely to be a problem when cellulose is used as an excipient in pharmaceutical formulations.
Deliberate abuse of formulations containing cellulose, either by inhalation or by injection, has resulted in the formation of cellulose granulomas.


Microcrystalline cellulose and carboxymethylcellulose sodium is hygroscopic and should not be exposed to moisture. It is stable over a pH range of 3.5–11. Store in a cool, dry place. Avoid exposure to excessive heat.

비 호환성

Microcrystalline cellulose is incompatible with strong oxidizing agents.

Regulatory Status

Microcrystalline cellulose and carboxymethylcellulose sodium is a mixture of two materials both of which are generally regarded as nontoxic:
Microcrystalline cellulose GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; oral capsules, powders, suspensions, syrups, and tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Carboxymethylcellulose sodium GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; intra-articular, intrabursal, intradermal, intralesional, and intrasynovial injections; oral drops, solutions, suspensions, syrups and tablets; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

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