3,6-dibromopyrazin-2-amine
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3,6-dibromopyrazin-2-amine 속성
- 끓는 점
- 314℃
- 밀도
- 2.287
- 인화점
- 144℃
- 저장 조건
- under inert gas (nitrogen or Argon) at 2–8 °C
- 산도 계수 (pKa)
- 0.05±0.10(Predicted)
- 수용성
- 물에 약간 용해됩니다.
- InChI
- InChI=1S/C4H3Br2N3/c5-2-1-8-3(6)4(7)9-2/h1H,(H2,7,9)
- InChIKey
- ZEDFFSRZLCREEN-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(Br)=CN=C1Br
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
3,6-dibromopyrazin-2-amine C화학적 특성, 용도, 생산
용도
It is used as a pharmaceutical intermediate.Synthesis
Diphenylphosphoryl azide (488 mg, 1.77 mmol) and triethylamine (180 mg, 1.77 mmol) were added to a solution of the acid (500 mg, 1.77 mmol) in tert-butanol (12 mL). The reaction mixture was stirred at reflux for 18 h and then quenched with water. The volatiles were removed under reduced pressure. The residue was dissolved in 4:1 TFA/DCM (5 mL) and stirred at rt for 1 h. The volatiles were removed under reduced pressure. The residue was dissolved in DCM and washed with 1N aq. NaOH. The combined organic extracts were dried (Na2SO4), filtered and concentrated. The crude residue was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient to afford 3,6-dibromopyrazin-2-amine 120 mg (27%) of bromoanisol as a colorless oil. MS m/z (ES): 253 (M+H)+.
3,6-dibromopyrazin-2-amine 준비 용품 및 원자재
원자재
tert-butyl (3,6-dibromopyrazin-2-yl)carbamate
3,6-dibroMopyrazine-2-carboxaMide
3,6-dibroMopyrazine-2-carboxylic acid
준비 용품
3,6-dibromopyrazin-2-amine 공급 업체
글로벌( 102)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 |
joe@yuhengpharm.com | CHINA | 21149 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 |
shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 |
alfa4@alfachem.cn | China | 12755 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 |
contact@labnetwork.com | China | 19994 | 58 |