유전적인 결함을 일으킬 수 있음 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)
생식세포 변이원성 물질
구분 1A, 1B
위험
예방조치문구:
P201
사용 전 취급 설명서를 확보하시오.
P308+P313
노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
3-Quinolinecarboxylic acid, 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo- C화학적 특성, 용도, 생산
개요
Finafloxacin, an antimicrobial agent of the 8-cyano subclass of
fluoroquinolones, was approved by the US FDA in December
2014 for treatment of acute otitis externa, commonly known as
swimmer’s ear, caused by susceptible strains of Pseudomonas
aeruginosa and Staphylococcus aureus. Finafloxacin was
developed by MerLion Pharmaceuticals in partnership with Bayer
Health Care Pharmaceuticals, and the drug was licensed by Mer-
Lion to Alcon (a division of Novartis) for development and commercialization
for ear infections in North America. In
contrast to other marketed fluoroquinolones, which display
reduced activity in slightly acidic environments, finafloxacin exhibits
increased antibacterial activity at pH 5–6, with minimum inhibitory
concentration values that are 4- to 8-fold lower than at
neutral pH. It is highly selective for bacterial type II topoisomerases,
which are involved in bacterial DNA replication, transcription,
repair, and recombination, and has broad spectrum
antibacterial activity against Gram-positive and Gram-negative
strains, including ciprofloxacin-resistant strains.
용도
Used for the preparation of naphthyridonecarboxylic acid derivatives as drugs for therapy of Helicobacter pylori infections and associated gastroduodenal illnesses.
정의
ChEBI: A quinolone that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted at positions 1, 6, 7 and 8 by cyclopropyl, fluoro, hexahydropyrrolo[3,4-b][1,4]oxazin-6-yl and cyano groups respectively; an antibiotic used for treatment of
acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus.
3-Quinolinecarboxylic acid, 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo- 준비 용품 및 원자재
원자재
준비 용품
3-Quinolinecarboxylic acid, 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo- 공급 업체
