ABC294640

ABC294640 구조식 이미지
카스 번호:
915385-81-8
상품명:
ABC294640
동의어(영문):
CS-802;ABC294640;ABC294640(Opaganib);Opaganib (ABC294640);3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide;3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide;Tricyclo[3.3.1.13,7]decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl);3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.1(3,7)]decane-1-carboxamide;ABC294640;ABC-294640;ABC 294640;3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE.;ABC294640; ABC-294640; ABC 294640; 3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE;OPAGANIB
CBNumber:
CB42624930
분자식:
C23H25ClN2O
포뮬러 무게:
380.91
MOL 파일:
915385-81-8.mol

ABC294640 속성

끓는 점
589.5±50.0 °C(Predicted)
밀도
1.273±0.06 g/cm3(Predicted)
저장 조건
Inert atmosphere,Store in freezer, under -20°C
용해도
≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
14.57±0.40(Predicted)
안전
  • 위험 및 안전 성명
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
NFPA 704
0
2 0

ABC294640 C화학적 특성, 용도, 생산

개요

ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2; Ki = 9.8 μM). It inhibits SPHK2 (IC50 = 60 μM) without affecting SPHK1 activity up to 100 μM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-AI) cells via an SPHK1-indirect, proteasomal-dependent mechanism when used at concentrations ranging from 5 to 25 μM. ABC294640 is inactive against a panel of 20 lipid-regulated kinases at 50 μM. It decreases sphingosine-1-phosphate (S1P) production in MDA-MB-231 cells in a concentration-dependent manner. ABC294640 inhibits proliferation of a variety of cancer cells, including HepG2 liver, A-498 kidney, PANC-1 pancreas, and HT-29 colon cells (IC50s = 6, 12.2, 32.8, and 48.1 μM, respectively). It reduces actin filament polymerization in, and cell migration of, A-498 cells in a scratch assay. Oral administration of ABC294640 (35 and 100 mg/kg every other day) reduces tumor growth in a mouse syngeneic model of mammary adenocarcinoma. It also reduces colonic inflammation in mouse and rat models of Crohn’s disease induced by trinitrobenzene sulfonic acid (TNBS).

용도

Opaganib is used in treating iatrogenic autoimmune colitis.

ABC294640 준비 용품 및 원자재

원자재

준비 용품


ABC294640 공급 업체

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ATK CHEMICAL COMPANY LIMITED
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career henan chemical co
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Fuxin Pharmaceutical
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Zhejiang J&C Biological Technology Co.,Limited
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InvivoChem
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TargetMol Chemicals Inc.
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support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8475 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 132020 58
Wuhan Biocar Pharmacy Co., Ltd. +86-13669031409 +8613669031409
jason@biocar.cn China 742 58

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