CC0651
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CC0651 속성
- 끓는 점
- 755.7±60.0 °C(Predicted)
- 밀도
- 1.410±0.06 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- DMSO: ≥ 56 mg/mL (126.61 mM)
- 산도 계수 (pKa)
- 3.37±0.34(Predicted)
- 물리적 상태
- 가루
안전
CC0651 C화학적 특성, 용도, 생산
일반 설명
A cell-permeable biphenylylpentanoic acid compound that acts as a selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC50 = 2.5 μM in a Sic1-SCFCdc4 assay) without affecting the activities of E1 or E3 ligases. Reported to act by trapping a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site and may serve as a molecular bridge between Cdc34A and ubiquitin. Binds to Cdc34ACAT alone with an EC50 value of 267 μM, but in the presence of ubiquitin, this affinity is significantly increased (EC50 = 19 μM). Does not disrupt the interaction of Cdc34A with the RING domain of Rbx1 and is suggested to even moderately stabilize this interaction. Shown to inhibit p27Kip1 ubiquitination (IC50 = 1.72 μM) and reduce PC-3 cancer cells proliferation (~30 μM).Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yesCC0651 준비 용품 및 원자재
원자재
준비 용품
CC0651 공급 업체
글로벌( 35)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 |
info@chemexpress.com | China | 7553 | 61 |
MedChemexpress LLC | 021-58955995 |
sales@medchemexpress.cn | United States | 4863 | 58 |
LETOPHARM LIMITED | +86-21-5821 5861 |
sales@letopharm.com | China | 2384 | 58 |
SPIRO PHARMA | |
eric_feng1954@126.com | China | 9254 | 55 |
Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 |
505721671@qq.com | China | 3868 | 58 |
Musechem | +1-800-259-7612 |
info@musechem.com | United States | 4662 | 60 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
CC0651 관련 검색:
CHLOROETHANE
TDZD-8
4SC-202
CEP-32496
N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
PURVALANOL A
Testolactone
GDC-0077
AGI6780
6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
IDO-IN-7
UNC 0631
XL 228
N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea