SGI-1027
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SGI-1027 속성
- 녹는점
- >280℃
- 밀도
- 1.387±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO에 용해됨(최대 35mg/ml)
- 산도 계수 (pKa)
- 13.31±0.70(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 밝은 갈색까지
- 안정성
- 공급된 상태로 2년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
안전
SGI-1027 C화학적 특성, 용도, 생산
용도
SGI-1027 is a quinoline derivative and a potent inhibitor of DNA methyltransferase (DNMT). SGI-1027 can be used as a potential therapeutic agent for the treatment of cancer and other diseases and also as a research tool to investigate the role of DNMTs in epigenetic events.Biochem/physiol Actions
SGI-1027 is a DNA methyltransferase (DNMT) inhibitor with IC50 values of 6-13 μM for DNMT3B, DNMT3A and DNMT1. SGI-1027 directly inhibits DNMT activity by competing with the cofactor, S-adenosylmethionine (SAM) in the methylation reaction. SGI-1027 treatment of cancer cell lines induced degradation of DNMT1, but not DNMT3A or DNMT3B, and in RKO cells caused re-expression of the silenced tumor supressor genes p16, MLH1 and TIMP3.SGI-1027 준비 용품 및 원자재
원자재
ethyl 4-(quinolin-4-ylamino)benzoate
4-(QUINOLIN-4-YLAMINO)-BENZOIC ACID
2,4-Pyrimidinediamine, N4-(4-aminophenyl)-6-methyl-
2,4-Pyrimidinediamine, 6-methyl-N4-(4-nitrophenyl)-
Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-nitro-
4-Chloroquinoline
2-Amino-4-chloro-6-methylpyrimidine
4-aMino-N-(4-(2-aMino-6-MethylpyriMidin-4-ylaMino)phenyl)benzaMide
p-아미노안식향산에틸에스테르
4-나이트로아닐린
준비 용품
SGI-1027 공급 업체
글로벌( 88)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; |
laboratory@coreychem.com | China | 30255 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29271 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 |
cbc@coresyn.com | China | 9991 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 |
trendseenbio@gmail.com | China | 11681 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |