LDE-225 Diphosphate

LDE-225 Diphosphate C화학적 특성, 용도, 생산

개요

Sonidegib phosphate (XXIX), an orally bioavailable, small molecule smoothened (SMO) receptor antagonist developed by Novartis, was approved in 2015 in Switzerland, the U.S., and the EU for the treatment of adult patients with advanced or locally advanced basal cell carcinoma (BCC). BCC is the most frequently diagnosed skin cancer, constituting 80% of all nonmelanoma skin cancers. While most BCCs can be treated through surgery or radiation therapy, some patients (<10%) have more advanced tumors for which surgery may be contraindicated or impractical; treatment options for these patients are limited. SMO, a G-protein coupled receptor-like protein (GPCR), is a key regulator in the hedgehog (Hh) pathway, which is activated in a number of tumors including BCC. In a multicenter clinical trial for sonidegib, an objective response rate of 43% was observed for patients with locally advanced BCC (dosing at 200 mg once daily), with sustained clinically meaningful responses based on an 18-month analysis. Sonidegib joins vismodegib as marketable treatments of BCC. Vismodegib, which was approved in 2012 as a first-in-class SMO receptor antagonist, represented the first Hedgehog signaling pathway targeting agent to gain FDA approval.

용도

NVP-LDE225 Diphosphate Salt is a potent, selective, and orally bioavailable Smoothened (Hedgehog Signaling Pathway) antagonist.

정의

ChEBI: A phosphate salt obtained by reaction sonidegib with two equivalent of phosphoric acid. Used for treatment of locally advanced basal cell carcinoma.

LDE-225 Diphosphate 준비 용품 및 원자재

원자재

준비 용품

LDE-225 Diphosphate 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Nanjing Fred Technology Co., Ltd	+86-25-84696168 +86-15380713688	Austin@fredbio.com	China	2449	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Beijing Jingzi Pharmaceutical Technology Co., Ltd.	15011485209	17241816@qq.com	China	81	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55

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