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ODM-201

ODM-201 구조식 이미지
카스 번호:
1297538-32-9
상품명:
ODM-201
동의어(영문):
0DM021;ODM-201;ODM-021;ODM 021;CS-1565;BAY-1841788;Darolutamid;Darolutamide;Darolutamide D4;ODM-201(BAY-1841788)
CBNumber:
CB43052901
분자식:
C19H19ClN6O2
포뮬러 무게:
398.85
MOL 파일:
1297538-32-9.mol

ODM-201 속성

끓는 점
719.5±60.0 °C(Predicted)
밀도
1.41±0.1 g/cm3(Predicted)
산도 계수 (pKa)
11.10±0.10(Predicted)

안전

ODM-201 C화학적 특성, 용도, 생산

개요

ODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the  testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.

참고 문헌

Moilanen, Anu Maarit, et al. "Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies." Sci Rep 5.2(2015):12007. Fizazi, Karim, et al. "ODM-201, a new generation androgen receptor inhibitor for castration-resistant prostate cancer: Preclinical and phase I data." Genitourinary Cancers Symposium of the Conquer-Cancer-Foundation of 2013. Fizazi, K, et al. "Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial." Lancet Oncology 5.9(2014):975-85.

ODM-201 준비 용품 및 원자재

원자재

준비 용품


ODM-201 공급 업체

글로벌( 93)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Shenzhen Excellent Biotech Co., Ltd.
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ATK CHEMICAL COMPANY LIMITED
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career henan chemical co
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BOC Sciences
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Chongqing Chemdad Co., Ltd
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sales@chemdad.com CHINA 37282 58
Target Molecule Corp
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